ArticleThe journal of obstetrics and gynaecology research2021
Cardiovascular risk factors before and during pregnancy: Does pregnancy unmask or initiate risk?
Article in The journal of obstetrics and gynaecology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- The effect of gestational diabetes mellitus on carotid artery intima-media thickness in and after pregnancy: a systematic review and meta-analysis.Acta diabetologica · 2024Pooled it
- Pregnancy as a Window for Hypertension and Cardiovascular Prevention in Women: A Life-Course Perspective Based on the 2025 ESC Guidelines.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Review
- Cardiovascular Risk During Pregnancy: Scoping Review on the Clinical Implications and Long-Term Consequences.Journal of clinical medicine · 2025Review
- Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes.Scientific reports · 2025Article
- Reference Intervals for Common Biochemistry and Hematology Parameters in Early Pregnancy-A Prospective Study.Diagnostics (Basel, Switzerland) · 2025Article
- Review
- Pregnancy-Related Complications and Incidence of Atrial Fibrillation: A Systematic Review.Journal of clinical medicine · 2023Review
- [Retrospective analysis of 35 burn patients in different stages of pregnancy].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Observational
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 4 countries.
Funding
Abstract
objectivesTo understand if pregnancy unmasks previously silent cardiovascular (CV) adverse factors, or initiates lasting injury.
methodsPre-pregnancy and during pregnancy CV risk factors (blood pressure, fasting lipids, and glucose) from 296 women belonging to studies in the International Childhood Cardiovascular Cohort (i3C) Consortium, a group of studies assessing the relationship between child and adolescent CV risk factors and adult outcomes, were used. Correlation coefficients between the pre- and during pregnancy measures were calculated, and the mean difference between the measures was modeled with adjustment for age, body mass index, race, smoking, and study.
resultsMeasures were strongly correlated at pre- and during-pregnancy visits (p < 0.01), with r of between 0.30 and 0.55. In most cases, the difference between pre-pregnancy and during-pregnancy did not differ significantly from 0 after adjustment for confounders. Stratification by gestational age indicated stronger correlations with measurements obtained during the first and second trimesters than the third. The correlation did not differ by the time elapsed between the pre-pregnancy and pregnancy visits.
conclusionsPre- and during-pregnancy CV risk factors are moderately well correlated. This may indicate that susceptible women enter pregnancy with higher risk rather than pregnancy inducing new vascular or metabolic effects.
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Registered trials
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