Evidence map›Paper›PMID 34482475›Full record

ArticleAmino acids2021

Antimicrobial peptidomes of Bothrops atrox and Bothrops jararacussu snake venoms.

Cleópatra Alves da Silva Caldeira, Rafaela Diniz-Sousa, Daniel Carvalho Pimenta, Ana Paula Azevedo Dos Santos, Carolina Bioni Garcia Teles, Najla Benevides Matos, Saulo Luís da Silva, Rodrigo Guerino Stabeli, Silvia Andrea Camperi, Andreimar Martins Soares and 1 more

Abstract read
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In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Molecular interaction assaysThe journal of venomous animals and toxins including tropical diseases · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Cleópatra Alves da Silva CaldeiraCenter for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, RO, Brazil. cleopatra@unir.br.ORCID https://orcid.org/0000-0003-1670-5227
Rafaela Diniz-SousaCenter for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, RO, Brazil.
Daniel Carvalho PimentaBiochemistry and Biophysics Laboratory, Butantan Institute, Sao Paulo, SP, Brazil.
Ana Paula Azevedo Dos SantosGraduate Program in Experimental Biology (PGBIOEXP), Federal University of Rondônia (UNIR), Porto Velho, RO, Brazil.
Carolina Bioni Garcia TelesGraduate Program in Biodiversity and Biotechnology, BIONORTE Network, Porto Velho, RO, Brazil.
Najla Benevides MatosMicrobiology Laboratory, Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Research Center on Tropical Medicine of Rondônia (CEPEM), Porto Velho, RO, Brazil.
Saulo Luís da SilvaCollege of Biochemistry and Pharmacy, Faculty of Chemical Sciences, University of Cuenca, Cuenca, Azuay, Ecuador.
Rodrigo Guerino StabeliTranslational Medicine Platform, Fiocruz, Ribeirão Preto, São Paulo, Brazil.
Silvia Andrea CamperiUniversidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Biotecnología, Buenos Aires, Argentina.
Andreimar Martins SoaresCenter for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, RO, Brazil.
Leonardo de Azevedo CalderonCenter for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, RO, Brazil. calderon@unir.br.
Universidade Federal de Rondônia · BRFundação Oswaldo Cruz · BRInstituto Butantan · BRUniversidad de Buenos Aires · ARUniversidade do Porto · PTUniversidade Federal de São Carlos · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303792/2016-1Conselho Nacional de Desenvolvimento Científico e Tecnológico # 406385/2018Financiadora de Estudos e Projetos 01.09.0278.04Universidad de Buenos Aires # 01.12.0450.0
6 · The paper itself

Abstract

The worrisome emergence of pathogens resistant to conventional drugs has stimulated the search for new classes of antimicrobial and antiparasitic agents from natural sources. Antimicrobial peptides (AMPs), acting through mechanisms that do not rely on the interaction with a specific receptor, provide new possibilities for the development of drugs against resistant organisms. This study sought to purify and proteomically characterize the antimicrobial and antiparasitic peptidomes of B. atrox and B. jararacussu snake venoms against Gram-positive (Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus-MRSA), Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) bacteria, and the protozoan parasites Leishmania amazonensis and Plasmodium falciparum (clone W2, resistant to chloroquine). To this end, B. atrox and B. jararacussu venom peptides were purified by combination of 3 kDa cut-off Amicon

Indexed as

AnimalsAnti-Bacterial AgentsAnti-Infective AgentsAntimalarialsBothropsCrotalid VenomsHemolytic AgentsHumansLeishmaniaMicrobial Sensitivity TestsPeptidesPlasmodium falciparumPseudomonas aeruginosaSpectrometry, Mass, Electrospray IonizationStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsAntimalarialsCrotalid VenomsHemolytic AgentsPeptidesAntimicrobial peptideBothrops atroxBothrops jararacussuPeptidomicsSnake venom peptidome

Identifiers

PMID34482475
OpenAlexW3197700490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.