ArticleBrain structure & function2022
Distribution of brain oxytocin and vasopressin V1a receptors in chimpanzees (Pan troglodytes): comparison with humans and other primate species.
Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Romantic love as regulatory co-option of maternal-bonding circuitry: a testable genetic account.Frontiers in behavioral neuroscience · 2026Article
- Oxytocin and vasopressin enhance social pain empathy via common and distinct of neural expressions, genetic pathways, and networks.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- Neuropeptide receptor distributions in male and femaleBiology letters · 2025Article
- GABA receptor antagonism elicits feeding in the septohypothalamic nucleus.Frontiers in behavioral neuroscience · 2025Article
- Nebulized vasopressin penetrates CSF and improves social cognition without inducing aggression in a rhesus monkey model of autism.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Oxytocin and our place in the universe.Comprehensive psychoneuroendocrinology · 2024Review
- Intranasal oxytocin does not change partner preference in female titi monkeys (Plecturocebus cupreus), but intranasal vasopressin decreases it.Journal of neuroendocrinology · 2023Article
- Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes.Physiological reviews · 2023Review
- Modulation of social behavior by distinct vasopressin sources.Frontiers in endocrinology · 2023Review
- Oxytocin receptors are widely distributed in the prairie vole (Microtus ochrogaster) brain: Relation to social behavior, genetic polymorphisms, and the dopamine system.The Journal of comparative neurology · 2022Article
- Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities.Endocrinology · 2022Review
- Plasma Testosterone and Androstenedione Levels Follow the Same Sex-Specific Patterns in the TwoBiology · 2022Article
- Leveraging a translational research approach to drive diagnostic and treatment advances for autism.Molecular psychiatry · 2022Review
- Neuroimaging of human and non-human animal emotion and affect in the context of social relationships.Frontiers in behavioral neuroscience · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Despite our close genetic relationship with chimpanzees, there are notable differences between chimpanzee and human social behavior. Oxytocin and vasopressin are neuropeptides involved in regulating social behavior across vertebrate taxa, including pair bonding, social communication, and aggression, yet little is known about the neuroanatomy of these systems in primates, particularly in great apes. Here, we used receptor autoradiography to localize oxytocin and vasopressin V1a receptors, OXTR and AVPR1a respectively, in seven chimpanzee brains. OXTR binding was detected in the lateral septum, hypothalamus, medial amygdala, and substantia nigra. AVPR1a binding was observed in the cortex, lateral septum, hypothalamus, mammillary body, entire amygdala, hilus of the dentate gyrus, and substantia nigra. Chimpanzee OXTR/AVPR1a receptor distribution is compared to previous studies in several other primate species. One notable difference is the lack of OXTR in reward regions such as the ventral pallidum and nucleus accumbens in chimpanzees, whereas OXTR is found in these regions in humans. Our results suggest that in chimpanzees, like in most other anthropoid primates studied to date, OXTR has a more restricted distribution than AVPR1a, while in humans the reverse pattern has been reported. Altogether, our study provides a neuroanatomical basis for understanding the function of the oxytocin and vasopressin systems in chimpanzees.
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