ReviewMikrochimica acta2021
Analyzing the surface of functional nanomaterials-how to quantify the total and derivatizable number of functional groups and ligands.
Review in Mikrochimica acta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Cross-validation of analytical methods for citrate ligand quantification on upconversion and iron oxide nanoparticles.Analytical and bioanalytical chemistry · 2026Article
- Quantification of the amount of surface groups of aminated silica nano- and microparticles utilizing a fluorine tag and HR-CS-GFMAS.Analytical and bioanalytical chemistry · 2026Article
- Enhancing antitumor immunity in triple-negative breast cancer through reversal of T-cell exhaustion using a CD8-targeted and membrane-camouflaged nanocarrier delivering small interfering RNA against sorting Nexin 9.Journal of nanobiotechnology · 2026Article
- Optimization of M1 macrophage targeting using a glucosylated albumin nanoplatform for ROS scavenging and mitochondrial rescue in acute kidney injury.Journal of nanobiotechnology · 2026Article
- Fabrication and Characterization of Xylomannan/FeInternational journal of fertility & sterility · 2026Article
- Comparison of the effects of metformin, citral, Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats.Animal models and experimental medicine · 2025Article
- Quantifying surface groups on aminated silica nanoparticles of different size, surface chemistry, and porosity with solution NMR, XPS, optical assays, and potentiometric titration.Nanoscale advances · 2025Article
- Expanding the Toolbox of Simple, Cost-Efficient, and Automatable Methods for Quantifying Surface Functional Groups on NanoparticlesPotentiometric Titration.ACS measurement science au · 2025Article
- A Review on Biomedical, Biomolecular, and Environmental Monitoring Applications of Cysteamine Functionalized Nanomaterials.Micromachines · 2025Review
- Quantifying Citrate Surface Ligands on Iron Oxide Nanoparticles with TGA, CHN Analysis, NMR, and RP-HPLC with UV Detection.Analytical chemistry · 2025Article
- Effects of LinTT1-peptide conjugation on the properties of poly(ethylene glycol)-block-(ε-caprolactone) nanoparticles prepared by the nanoprecipitation method.Drug delivery and translational research · 2025Article
- Innovative In Situ Interfacial Co-Assembled Lignin/Chitosan Nanoparticles-Green Synthesis, Physicochemical Characterization, In Vitro Release, and Intermolecular Interactions.International journal of molecular sciences · 2025Article
- Spontaneous and Laccase-Assisted Adsorption of Hemicelluloses Rendering Colloidal Stability of Lignin Nanoparticles at Low pH.ChemSusChem · 2025Article
- The Application of Anisotropically Collapsing Gels, Deep Learning, and Optical Microscopy for Chemical Characterization of Nanoparticles and Nanoplastics.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Influence of Surface Chemistry on Metal Deposition Outcomes in Copper Selenide-Based Nanoheterostructure Synthesis.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Polymeric nanocarrier-based adjuvants to enhance a locally produced mucosal coryza vaccine in chicken.Scientific reports · 2024Article
- Efficient synthesis of benzoacridines and indenoquinolines catalyzed by acidic magnetic dendrimer.Scientific reports · 2024Article
- Molecular Surface Quantification of Multifunctionalized Gold Nanoparticles Using UV-Visible Absorption Spectroscopy Deconvolution.Analytical chemistry · 2023Article
- Influence of nanoparticle encapsulation and encoding on the surface chemistry of polymer carrier beads.Scientific reports · 2023Article
- Quantum Annealing Boosts Prediction of Multimolecular Adsorption on Solid Surfaces Avoiding Combinatorial Explosion.JACS Au · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Functional nanomaterials (NM) of different size, shape, chemical composition, and surface chemistry are of increasing relevance for many key technologies of the twenty-first century. This includes polymer and silica or silica-coated nanoparticles (NP) with covalently bound surface groups, semiconductor quantum dots (QD), metal and metal oxide NP, and lanthanide-based NP with coordinatively or electrostatically bound ligands, as well as surface-coated nanostructures like micellar encapsulated NP. The surface chemistry can significantly affect the physicochemical properties of NM, their charge, their processability and performance, as well as their impact on human health and the environment. Thus, analytical methods for the characterization of NM surface chemistry regarding chemical identification, quantification, and accessibility of functional groups (FG) and surface ligands bearing such FG are of increasing importance for quality control of NM synthesis up to nanosafety. Here, we provide an overview of analytical methods for FG analysis and quantification with special emphasis on bioanalytically relevant FG broadly utilized for the covalent attachment of biomolecules like proteins, peptides, and oligonucleotides and address method- and material-related challenges and limitations. Analytical techniques reviewed include electrochemical titration methods, optical assays, nuclear magnetic resonance and vibrational spectroscopy, as well as X-ray based and thermal analysis methods, covering the last 5-10 years. Criteria for method classification and evaluation include the need for a signal-generating label, provision of either the total or derivatizable number of FG, need for expensive instrumentation, and suitability for process and production control during NM synthesis and functionalization.
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Registered trials
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