Evidence map›Paper›PMID 34482434›Full record

ArticleJournal of neurology2022

COVID-19 manifestations in people with Parkinson's disease: a USA cohort.

Yaqian Xu, Matthew Surface, Amanda K Chan, Joshua Halpern, Nora Vanegas-Arroyave, Blair Ford, Megan P Feeney, Kimberly T Kwei, Linn E Katus, Sheng-Han Kuo and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  13. Spotlight on non-motor symptoms and Covid-19.International review of neurobiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Yaqian Xu *Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Matthew Surface *Department of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Amanda K ChanDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Joshua HalpernDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Nora Vanegas-ArroyaveDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Blair FordDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Megan P FeeneyParkinson's Foundation, New York, NY, USA.
Kimberly T KweiDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Linn E KatusDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Sheng-Han KuoDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Hiral ShahDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Cheryl WatersDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Linda M WinfieldDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
James C BeckParkinson's Foundation, New York, NY, USA.
Serge PrzedborskiDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Stanley FahnDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA.
Roy N AlcalayDepartment of Neurology, Columbia University Irving Medical Center, 710 West 168th St., New York, NY, 10025, USA. rna2104@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-5717-4875
Columbia University Irving Medical Center · USParkinson's Foundation · USBaylor College of Medicine · US

Funding

A transcriptomic atlas of immune cells in a model of synucleinopathyR21AG064596 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PRZEDBORSKI, SERGE E · 2019 to 2020
$446k
Focused ultrasound and synucleinopathyR21NS111176 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PRZEDBORSKI, SERGE E · 2019 to 2019
$446k
NIA NIH HHS R21 AG064596NINDS NIH HHS R21 NS111176
6 · The paper itself

Abstract

backgroundWith the explosion of COVID-19 globally, it was unclear if people with Parkinson's disease (PD) were at increased risk for severe manifestations or negative outcomes.

objectivesTo report on people with PD who had suspected or confirmed COVID-19 to understand how COVID-19 manifested in PD patients.

methodsWe surveyed PD patients who reported COVID-19 to their Movement Disorders specialists at Columbia University Irving Medical Center and respondents from an online survey administered by the Parkinson's Foundation that assessed COVID-19 symptoms, general clinical outcomes and changes in motor and non-motor PD symptoms.

resultsForty-six participants with PD and COVID-19 were enrolled. Similar to the general population, the manifestations of COVID-19 among people with PD were heterogeneous ranging from asymptomatic carriers (1/46) to death (6/46). The most commonly reported COVID-19 symptoms were fever/chills, fatigue, cough, weight loss, and muscle pain. Worsening and new onset of motor and non-motor PD symptoms during COVID-19 illness were also reported, including dyskinesia, rigidity, balance disturbances, anxiety, depression, and insomnia.

conclusionWe did not find sufficient evidence that PD is an independent risk factor for severe COVID-19 and death. Larger studies with controls are required to understand this further. Longitudinal follow-up of these participants will allow for observation of possible long-term effects of COVID-19 in PD patients.

Indexed as

COVID-19Parkinson DiseaseAnxietyHumansSARS-CoV-2Surveys and QuestionnairesCOVID-19Parkinson’s disease

Identifiers

PMID34482434
PMCPMC8418279
OpenAlexW3196518213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.