ArticleParkinsonism & related disorders2021
Features of "ET plus" correlate with age and tremor duration: "ET plus" may be a disease stage rather than a subtype of essential tremor.
Article in Parkinsonism & related disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Essential tremor patients experience significant burden beyond tremor: A systematic literature review.Frontiers in neurology · 2022Pooled it
- Magnetic resonance-guided focused ultrasound thalamotomy in essential tremor subtypes: a phenotype-based insight into gait and balance.Brain communications · 2026Article
- The Cerebellar Cognitive Affective Syndrome in Essential Tremor Plus.Cerebellum (London, England) · 2025Article
- The Relationship between Rest Tremor and Underlying Lewy Pathology in Essential Tremor: A Clinical-Pathological Study of 201 Cases.Annals of neurology · 2025Article
- Pathophysiological Role of Primary Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Serum glial fibrillary acidic protein is elevated in early-stage late-onset essential tremor and associated with tremor progression.Journal of neural transmission (Vienna, Austria : 1996) · 2025Observational
- Determinants of clinical and neurophysiological features in essential tremor and essential tremor plus.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Microstructural abnormalities of the dentato-rubro-thalamo-cortical tract in tremor dominant Parkinson's disease and essential tremor plus syndrome.Neuroradiology · 2025Article
- Corpus Callosum Structural Alterations in Essential Tremor with and Without Resting Tremor: A Multimodal MRI Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Differential patterns of functional connectivity in tremor dominant Parkinson's disease and essential tremor plus.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia: The TITAN Study.Movement disorders clinical practice · 2024Article
- Six Myths and Misconceptions about Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Review
- Combined cortical thickness and blink reflex recovery cycle to differentiate essential tremor with and without resting tremor.Frontiers in neurology · 2024Article
- Cortical involvement in essential tremor with and without rest tremor: a machine learning study.Journal of neurology · 2023Article
- Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China.Aging and disease · 2023Article
- Longitudinal study of clinical and neurophysiological features in essential tremor.European journal of neurology · 2023Article
- Developing a Staging Scheme for Essential Tremor: A Discussion of Organizing Principles.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Clinical correlates of "pure" essential tremor: the TITAN study.Frontiers in neurology · 2023Article
- Cerebellar voxel-based morphometry in essential tremor.Journal of neurology · 2022Article
- Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository.Journal of neuropathology and experimental neurology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEssential tremor (ET) is characterized by considerable clinical heterogeneity. In 2018, the term "ET plus" was introduced to mark a potential stratification point for dividing ET into subtypes - ET vs ET plus (i.e., ET cases with neurological features other than action tremor). However, as ET progresses, patients often develop increasingly severe tremor, spread of tremor, tremor under different activation conditions, and other features. Given this situation, ET plus may represent a disease stage rather than a disease classification or subtype. In theory, if the defining characteristics of a disease subtype fluctuate with age or disease duration, it raises the distinct possibility the "subtype" is a disease stage.
methodsA cohort of 241 prospectively enrolled ET cases underwent a detailed motor and cognitive assessment in which the features of ET plus including cerebellar signs (intention tremor, tandem gait difficulty), rest tremor, dystonia, and cognitive performance were evaluated. We determined whether these features of ET plus correlated with action tremor duration and age.
resultsWe demonstrated that numerous ET plus features were significantly correlated with both age and action tremor duration (numerous p values < 0.05). The same relationships were observed in a series of sensitivity analyses.
conclusionWe observed that the component parts of ET plus are highly age- and stage-dependent. These features are yearly-changing features conditional on a demographic and disease stage variable. These data support the notion that ET plus may represent a disease stage rather than a distinct disease subtype or disease classification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.