Evidence map›Paper›PMID 34482171›Full record

ReviewBioorganic chemistry2021

Biological evaluation and synthesis of calcitroic acid.

Olivia B Yu, Daniel A Webb, Elliot S Di Milo, Tania R Mutchie, Kelly A Teske, Taosheng Chen, Wenwei Lin, Carole Peluso-Iltis, Natacha Rochel, Moritz Helmstädter and 2 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioorganic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Olivia B YuDepartment of Chemistry and Biochemistry and Milwaukee Institute for Drug Discovery (MIDD), University of Wisconsin, 3210 N Cramer Street, Milwaukee, WI 53211, USA.
Daniel A WebbDepartment of Chemistry and Biochemistry and Milwaukee Institute for Drug Discovery (MIDD), University of Wisconsin, 3210 N Cramer Street, Milwaukee, WI 53211, USA.
Elliot S Di MiloDepartment of Chemistry and Biochemistry and Milwaukee Institute for Drug Discovery (MIDD), University of Wisconsin, 3210 N Cramer Street, Milwaukee, WI 53211, USA.
Tania R MutchieDepartment of Chemistry and Biochemistry and Milwaukee Institute for Drug Discovery (MIDD), University of Wisconsin, 3210 N Cramer Street, Milwaukee, WI 53211, USA.
Kelly A TeskeDepartment of Chemistry and Biochemistry and Milwaukee Institute for Drug Discovery (MIDD), University of Wisconsin, 3210 N Cramer Street, Milwaukee, WI 53211, USA.
Taosheng ChenDepartment of Chemical Biology and Therapeutics, 262 Danny Thomas Place, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Wenwei LinDepartment of Chemical Biology and Therapeutics, 262 Danny Thomas Place, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Carole Peluso-IltisInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM, U1258/CNRS, UMR 7104, University of Strasbourg, 67404 Illkirch, France.
Natacha RochelInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM, U1258/CNRS, UMR 7104, University of Strasbourg, 67404 Illkirch, France.
Moritz HelmstädterInstitute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
Daniel MerkInstitute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany.
Leggy A ArnoldDepartment of Chemistry and Biochemistry and Milwaukee Institute for Drug Discovery (MIDD), University of Wisconsin, 3210 N Cramer Street, Milwaukee, WI 53211, USA. Electronic address: arnold2@uwm.edu.
University of Wisconsin–Milwaukee · USGoethe University Frankfurt · DESt. Jude Children's Research Hospital · USCentre National de la Recherche Scientifique · FRUniversité de Strasbourg · FR

Funding

Small molecule inhibitors of the vitamin D receptor-coactivator interactionR03DA031090 · NIDA · UNIVERSITY OF WISCONSIN MILWAUKEE · PI ARNOLD, ALEXANDER · 2010 to 2011
$73k
NIDA NIH HHS R03 DA031090
6 · The paper itself

Abstract

We describe the synthesis and broad profiling of calcitroic acid (CTA) as vitamin D receptor (VDR) ligand. The x-ray co-crystal structure of the Danio Rerio VDR ligand binding domain in complex with CTA and peptide MED1 confirmed an agonistic conformation of the receptor. CTA adopted a similar conformation as 1,25(OH)

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCalcitriolCytokinesDose-Response Relationship, DrugHEK293 CellsHumansLipopolysaccharidesMiceMolecular ConformationRAW 264.7 CellsReceptors, CalcitriolStructure-Activity RelationshipAnti-Inflammatory Agents, Non-SteroidalCalcitriolcalcitroic acidCytokinesLipopolysaccharidesReceptors, CalcitriolCalcitroic acidCYP24A1IL-1βiNOSVitamin D receptor

Identifiers

PMID34482171
PMCPMC8592288
OpenAlexW3196596284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.