ArticleJournal of the American Academy of Child and Adolescent Psychiatry2022
Smaller Hippocampal Volume Among Black and Latinx Youth Living in High-Stigma Contexts.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Dementia-related stigma in physicians: a scoping review of stigma-reduction interventions.Frontiers in dementia · 2025Pooled it
- A research agenda for understanding how social inequality is linked to brain structure and function.Nature human behaviour · 2024Pooled it
- Country-level gender inequality is associated with structural differences in the brains of women and men.Proceedings of the National Academy of Sciences of the United States of America · 2023Pooled it
- Community-level explicit racial prejudice potentiates whites' neural responses to black faces: A spatial meta-analysis.Social neuroscience · 2022Pooled it
- AmygdalaGo-BOLT for boundary-aware segmentation of the human amygdala.Cell reports methods · 2026Article
- Racialized Heteroscedasticity in Neuroimaging Features, Behavior Measures, and Neuroimaging-Based Predictive Models.Research square · 2026Article
- Perceived Racism, Brain Development, and Internalizing and Externalizing Symptoms: Findings From the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- How Is Self-Compassion Associated with Prolonged Grief and Posttraumatic Stress After Bereavement? The Mediating Roles of Perceived Stigma and Anger.Behavioral sciences (Basel, Switzerland) · 2026Article
- Hippocampal Volume Moderates the Link between Racial-Ethnic Discrimination and Early Adolescent Depression.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- A Tale of Two Childhoods: State-Level Ethnoracism is Associated with Fewer Adverse Childhood Experiences (ACEs) for Non-Hispanic White Relative to Hispanic Youth.Journal of racial and ethnic health disparities · 2026Article
- Associations between amygdala connectivity and experienced discrimination in children.bioRxiv : the preprint server for biology · 2026Article
- Racial and Ethnic Differences in Suicide Mortality Among Youth Aged 12-25 Years Following Medical and Recreational Cannabis Legalization in the U.S.American journal of preventive medicine · 2026Article
- The Longitudinal Effects of Exclusionary School Discipline on Adolescent Well-Being.Research on child and adolescent psychopathology · 2025Article
- Structural Determinants of School Discipline: Examining State-Level Racial Bias and Neighborhood Opportunity.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- School Segregation During Adolescence is Associated with Higher 30-Year Cardiovascular Risk of Black but not White Young Adults.Journal of racial and ethnic health disparities · 2025Article
- Ethnic Identity Profiles Among Adolescents in the ABCD Study: Associations with Resting State Functional Connectivity and Perceived Discrimination.bioRxiv : the preprint server for biology · 2025Article
- Human development, inequality, and their associations with brain structure across 29 countries.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Associations between structural stigma and earlier pubertal timing persist for 1 year among Black girls and Latinx youth.Scientific reports · 2025Article
- State-level structural racism and sleep disturbances among Black and Latinx adolescents: Findings from the adolescent brain cognitive development study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Cross-Sectional Comparison of Structural MRI Markers of Impairment in a Diverse Cohort of Older Adults.Human brain mapping · 2025Article
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Funding
Abstract
objectiveTo determine whether structural and individual forms of stigma are associated with neurodevelopment in children.
methodStigma related to gender, race, and Latinx ethnicity was measured at the structural level using objective state-level indicators of social policies and prejudicial attitudes and at the individual level using self-reports of perceived discrimination. Respective associations of stigma with hippocampal volume and amygdala reactivity to threat were examined using data from the Adolescent Brain Cognitive Development (ABCD) Study (N = 11,534, mean age 9.9 years), the first multisite neuroimaging study that provided substantial variability in sociopolitical contexts and that included individual-level measures of stigma among youth.
resultsIn a preregistered analysis, Black (B = -58.26, p = .023) and Latinx (B = -40.10, p = .044) youths in higher (vs lower) structural stigma contexts were found to have smaller hippocampal volume, controlling for total intracranial volume, demographics, and family socioeconomic status. This association was also observed at a trend-level among girls (p = .082). The magnitude of the difference in hippocampal volume between high and low structural stigma states was equivalent to the predicted impact of a $20,000 difference in annual family income in this sample. As hypothesized, structural stigma was not associated with hippocampal volume in nonstigmatized youths, providing evidence of specificity. Perceived discrimination was unrelated to hippocampal volume in stigmatized groups. No associations between perceived discrimination or structural stigma and amygdala reactivity to threat were observed.
conclusionThis study provides novel evidence that an objective measure of structural stigma may be more strongly related to hippocampal volume than subjective perceptions of stigma, suggesting that contextual approaches to stigma could yield new insights into neurodevelopment among marginalized youth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.