ArticleMolecular brain2021
Assessing the effect of interaction between C-reactive protein and gut microbiome on the risks of anxiety and depression.
Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The microbiota-gut-brain-epigenome axis as a novel therapeutic target for decoding postpartum depression.Frontiers in medicine · 2026Pooled it
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- A reciprocal interaction between L-lysine andiMetaOmics · 2025Article
- Associations between gut microbiome and circulating cytokines: a cross-sectional analysis in the FINRISK 2002 population cohort.Gut pathogens · 2025Article
- Gut microbiota composition is related to anxiety and aggression scores in companion dogs.Scientific reports · 2025Article
- Soluble Human Lectins at the Host-Microbe Interface.Annual review of biochemistry · 2024Review
- Effects ofFrontiers in microbiology · 2024Article
- Gut microbiota and postpartum depression: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Zamzam Water Mitigates Cardiac Toxicity Risk through Modulation of GUT Microbiota and the Renin-angiotensin System.Current pharmaceutical design · 2024Article
- Improving precision management of anxiety disorders: a Mendelian randomization study targeting specific gut microbiota and associated metabolites.Frontiers in microbiology · 2024Article
- Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review.Frontiers in neuroscience · 2024Review
- Dangers of the chronic stress response in the context of the microbiota-gut-immune-brain axis and mental health: a narrative review.Frontiers in immunology · 2024Review
- C-Reactive Protein Levels Correlate with Measures of Dysglycemia and Gut Microbiome Profiles.Current microbiology · 2023Article
- C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.Diseases (Basel, Switzerland) · 2023Review
- Clarifying the effect of gut microbiota on allergic conjunctivitis risk is instrumental for predictive, preventive, and personalized medicine: a Mendelian randomization analysis.The EPMA journal · 2023Article
- Article
- Gut microbiota and sepsis: bidirectional Mendelian study and mediation analysis.Frontiers in immunology · 2023Article
- Alterations in the Gut Microbiota and Metabolomics of Seafarers after a Six-Month Sea Voyage.Microbiology spectrum · 2022Article
- Study of gut microbiota alterations in Alzheimer's dementia patients from Kazakhstan.Scientific reports · 2022Article
- Dysbiosis: A Potential Precursor to the Development of a Depressive Disorder.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Cumulative evidence shows that gut microbiome can influence brain function and behavior via the inflammatory processes. However, the role of interaction between gut dysbiosis and C-reactive protein (CRP) in the development of anxiety and depression remains to be elucidated. In this study, a total of 3321 independent single nucleotide polymorphism (SNP) loci associated with gut microbiome were driven from genome-wide association study (GWAS). Using individual level genotype data from UK Biobank, we then calculated the polygenetic risk scoring (PRS) of 114 gut microbiome related traits. Moreover, regression analysis was conducted to evaluate the possible effect of interaction between gut microbiome and CRP on the risks of Patient Health Questionnaire-9 (PHQ-9) (N = 113,693) and Generalized Anxiety Disorder-7 (GAD-7) (N = 114,219). At last, 11 candidate CRP × gut microbiome interaction with suggestive significance was detected for PHQ-9 score, such as F_Ruminococcaceae (β = - 0.009, P = 2.2 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.