Evidence map›Paper›PMID 34481512›Full record

ArticleJournal of medical case reports2021

Immunoglobulin G4 hypophysitis in a 63-year-old woman with no autoimmune history: a case report.

Zachary C Gersey, Kenan R Rajjoub, Thomas M Pearce, Scott A Segel, Paul A Gardner, Carl H Snyderman, Eric W Wang, Georgios A Zenonos

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zachary C GerseyDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St Suite B-400, Pittsburgh, PA, 15213, USA. gerseyzc@upmc.edu.ORCID http://orcid.org/0000-0002-4353-0779
Kenan R RajjoubDepartment of Neurological Surgery, The George Washington University School of Medicine, Washington, District of Columbia, USA.
Thomas M PearceDivision of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Scott A SegelDepartment of Endocrinology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Paul A GardnerDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St Suite B-400, Pittsburgh, PA, 15213, USA.
Carl H SnydermanDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Eric W WangDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Georgios A ZenonosDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St Suite B-400, Pittsburgh, PA, 15213, USA. zenonosg2@upmc.edu.
University of Pittsburgh Medical Center · USUniversity of Pittsburgh · USGeorge Washington University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunoglobulin-G4-related hypophysitis is a rare inflammatory disease that can present as a tumefactive pituitary lesion mimicking hypophyseal neoplasms such as pituitary adenoma or craniopharyngioma. The literature on this entity is sparse, with fewer than 100 cases reported across 19 publications; a recent review found only 24 cases published from 2007 to 2018. Previous reports have described demographic differences, with immunoglobulin-G4-related hypophysitis in females tending to present in the second and third decades in association with other autoimmune disease, while males tend to present in the fifth and sixth decades of life without an autoimmune history. CASE PRESENTATION: In contrast to the reported demographic trends, here we describe a unique case of immunoglobulin-G4-related hypophysitis in a 63-year-old white female with no history of autoimmune disease who presented with a rapidly enlarging sellar and hypothalamic mass causing headaches and cranial nerve palsies, prompting biopsy for diagnosis. The patient experienced rapid response to treatment with high-dose steroids and rituximab.

conclusionThe case contributes to the growing clinicopathologic description of immunoglobulin-G4-related hypophysitis and illustrates that this diagnosis should be a consideration even outside the conventional demographic setting.

Indexed as

CraniopharyngiomaHypophysitisPituitary DiseasesFemaleHumansImmunoglobulin GMaleMiddle AgedPituitary GlandImmunoglobulin GCase reportEndonasalHypophysitisIgG4Skull base

Identifiers

PMID34481512
PMCPMC8418724
OpenAlexW3198025596

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.