Evidence map›Paper›PMID 34481508›Full record

ArticleRespiratory research2021

SPECT imaging of pulmonary vascular disease in bleomycin-induced lung fibrosis using a vascular endothelium tracer.

François Harel, Quang T Nguyen, Mohamed J Nsaibia, Vincent Finnerty, Arielle Morgan, Martin Sirois, Louis Villeneuve, Angelino Calderone, Alexandre Bergeron, Emmanuelle Brochiero and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

François HarelMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Quang T NguyenMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Mohamed J NsaibiaMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Vincent FinnertyMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Arielle MorganMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Martin SiroisMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Louis VilleneuveMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Angelino CalderoneMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Alexandre BergeronMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Emmanuelle BrochieroDepartment of Medicine, Faculty of Medicine, Université de Montréal, 2900 Edouard-Montpetit Boulevard, Montreal, QC, H3T 1J4, Canada.
Jean-Claude TardifMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
YanFen ShiMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Jocelyn DupuisMontreal Heart Institute Research Center, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada. dupuisj@icloud.com.ORCID http://orcid.org/0000-0002-3193-1014
Montreal Heart Institute · CACentre Hospitalier de l’Université de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulmonary hypertension (PH) complicating idiopathic pulmonary fibrosis (IPF) is associated to worse outcome. There is a great need for a non-invasive diagnostic modality to detect and evaluate the severity of pulmonary vascular disease (PVD).

methodsRats with selective right lung bleomycin-induced fibrosis were compared to control rats. SPECT imaging was performed after three weeks with

resultsThe bleomycin group developed preferential right lung fibrosis with remodeling and reduced perfusion as assessed with fluorescent microangiography. These rats developed PH with RV hypertrophy and dysfunction.

conclusionsSPECT imaging with

Indexed as

AdrenomedullinAnimalsAntibiotics, AntineoplasticBleomycinEndothelium, VascularHypertension, PulmonaryMalePeptide FragmentsPulmonary FibrosisRadiopharmaceuticalsRatsRats, WistarTomography, Emission-Computed, Single-PhotonAdrenomedullinadrenomedullin (22-52), glycyl-glycyl-alanyl-glycyl-cysteinyl-(PEG)4-cysteinyl-Antibiotics, AntineoplasticBleomycinPeptide FragmentsRadiopharmaceuticalsAdrenomedullinMolecular imagingNuclear medicinePulmonary embolismPulmonary hypertension

Identifiers

PMID34481508
PMCPMC8418741
OpenAlexW3197444484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.