Evidence map›Paper›PMID 34481499›Full record

ArticleAnnals of clinical microbiology and antimicrobials2021

Molecular detection of bla

Trinh Van Son, Nguyen Dang Manh, Ngo Tat Trung, Dao Thanh Quyen, Christian G Meyer, Nguyen Thi Kim Phuong, Phan Quoc Hoan, Vu Viet Sang, Dennis Nurjadi, Thirumalaisamy P Velavan and 2 more

Open access · goldAbstract read
In one paragraph

Article in Annals of clinical microbiology and antimicrobials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Molecular characterization of ESBL-producingFrontiers in cellular and infection microbiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Occurrence of extended-spectrum β-lactamase-producing Enterobacteriaceae in raw milk from cows with subclinical mastitis in northeast Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Trinh Van Son *108 Institute of Clinical and Pharmaceutical Sciences, Hanoi, Vietnam.
Nguyen Dang Manh *108 Institute of Clinical and Pharmaceutical Sciences, Hanoi, Vietnam.
Ngo Tat Trung108 Institute of Clinical and Pharmaceutical Sciences, Hanoi, Vietnam.
Dao Thanh Quyen108 Institute of Clinical and Pharmaceutical Sciences, Hanoi, Vietnam.
Christian G MeyerVietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam.
Nguyen Thi Kim PhuongDepartment of Microbiology, 108 Military Central Hospital, Hanoi, Vietnam.
Phan Quoc HoanCentral Laboratory, 108 Military Central Hospital, Hanoi, Vietnam.
Vu Viet Sang108 Institute of Clinical and Pharmaceutical Sciences, Hanoi, Vietnam.
Dennis NurjadiDepartment of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
Thirumalaisamy P VelavanVietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam.
Mai Hong Bang *108 Institute of Clinical and Pharmaceutical Sciences, Hanoi, Vietnam.
Le Huu Song *108 Institute of Clinical and Pharmaceutical Sciences, Hanoi, Vietnam. lehuusong@108-icid.com.
Vietnamese - German Center of Excellence in Medical Research · VN108 Military Central Hospital · VNHanoi University of Pharmacy · VNHeidelberg University · DE

Funding

National Foundation for Science and Technology Development NAFOSTED:108.06-2017.21
6 · The paper itself

Abstract

backgroundBlood stream infections (BSI) caused by Extended Spectrum Beta-Lactamases (ESBLs) producing Enterobacteriaceae is a clinical challenge leading to high mortality, especially in developing countries. In this study, we sought to describe the epidemiology of ESBL-producing Escherichia coli strains isolated from Vietnamese individuals with BSI, to investigate the concordance of genotypic-phenotypic resistance, and clinical outcome of ESBL E. coli BSI.

methodsA total of 459 hospitalized patients with BSI were screened between October 2014 and May 2016. 115 E. coli strains from 115 BSI patients were isolated and tested for antibiotic resistance using the VITEK®2 system. The ESBL phenotype was determined by double disk diffusion method following the guideline of Clinical and Laboratory Standards Institute. Screening for beta-lactamase (ESBL and carbapenemase) genes was performed using a multiplex-PCR assay.

results58% (67/115) of the E. coli strains were ESBL-producers and all were susceptible to both imipenem and meropenem. Resistance to third-generation cephalosporin was common, 70% (81/115) were cefotaxime-resistant and 45% (52/115) were ceftazidime-resistant. bla

conclusionA high prevalence of ESBL-producing E. coli isolates harbouring bla

Indexed as

Bacteremiabeta-LactamasesCephalosporin ResistanceEscherichia coliEscherichia coli ProteinsHumansPhenotypeSepsisVietnamWhole Genome Sequencingbeta-LactamasesEscherichia coli ProteinsAMRAntimicrobial resistancesBlood stream infectionsCTX-MDrug-resistant Escherichia coliESBLSepsis

Identifiers

PMID34481499
PMCPMC8418716
OpenAlexW3198566687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.