Evidence map›Paper›PMID 34481495›Full record

ArticleJournal of nanobiotechnology2021

A self-amplified nanocatalytic system for achieving "1 + 1 + 1 > 3" chemodynamic therapy on triple negative breast cancer.

Lulu Zhou, Jinjin Chen, Yunhao Sun, Keke Chai, Zhounan Zhu, Chunhui Wang, Mengyao Chen, Wenmei Han, Xiaochun Hu, Ruihao Li and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Lulu Zhou *Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Jinjin Chen *Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Yunhao SunDepartment of Thoracic Surgery, First People's Hospital of Yancheng, Affiliated to Medical College of Nanjing University, Yancheng, Jiangsu, People's Republic of China.
Keke ChaiShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Zhounan ZhuShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Chunhui WangShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Mengyao ChenShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Wenmei HanShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Xiaochun HuShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Ruihao LiShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Tianming YaoShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Hui LiShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China.
Chunyan DongShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China. cy_dong@tongji.edu.cn.
Shuo ShiShanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, 200092, People's Republic of China. shishuo@tongji.edu.cn.ORCID http://orcid.org/0000-0003-4387-3445
Shanghai East Hospital · CNNantong University · CNTongji University · CN

Funding

national nature science foundation of china 21671150national nature science foundation of china 21877084national nature science foundation of china 81860547national nature science foundation of china 82073387Population and Family Planning Commission of Shandong Province PWRq2020-29Scientific Research Project of Shanghai Municipal Health Commission 20204Y0141Shanghai Pudong New Area Health and Family Planning Commission Leading Talent Training Program PWRI2019-07
6 · The paper itself

Abstract

backgroundChemodynamic therapy (CDT), employing Fenton or Fenton-like catalysts to convert hydrogen peroxide (H

resultsThe effective inhibition of PARP by Ola can synergize Lapa to enhance H

conclusionsThis design of nanocatalytic system offers a new paradigm for combing PARP inhibitor, NQO1-bioactivatable drug and Fenton-reagents to obtain sustained H

Indexed as

AnimalsAntineoplastic AgentsApoptosisCell Line, TumorDNA DamageHumansHydrogen PeroxideMiceNAD(P)H Dehydrogenase (Quinone)NanoparticlesNanostructuresNaphthoquinonesPoly (ADP-Ribose) Polymerase-1Reactive Oxygen SpeciesTriple Negative Breast NeoplasmsAntineoplastic Agentsbeta-lapachoneHydrogen PeroxideNAD(P)H Dehydrogenase (Quinone)NaphthoquinonesNQO1 protein, humanPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1Reactive Oxygen Species

Identifiers

PMID34481495
PMCPMC8418045
OpenAlexW3196685061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.