Evidence map›Paper›PMID 34481489›Full record

ArticleJournal of nanobiotechnology2021

Development of theranostic dual-layered Au-liposome for effective tumor targeting and photothermal therapy.

Miyeon Jeon, Gaeun Kim, Wooseung Lee, Seungki Baek, Han Na Jung, Hyung-Jun Im

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Miyeon Jeon *Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.
Gaeun Kim *Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.
Wooseung LeeDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.
Seungki BaekDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.
Han Na JungDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.
Hyung-Jun ImDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea. iiihjjj@gmail.com.ORCID http://orcid.org/0000-0002-4368-6685

Funding

ministry of health and welfare HI18C0886ministry of health and welfare HI19C0339National Research Foundation of Korea 2021M2E8A1039564National Research Foundation of Korea NRF-2019M2D2A1A01058210National Research Foundation of Korea NRF-2020R1C1C1009000seoul national university Creative-Pioneering Researchers Program
6 · The paper itself

Abstract

backgroundPhotothermal therapy (PTT) is an emerging anti-cancer therapeutic strategy that generates hyperthermia to ablate cancer cells under laser irradiation. Gold (Au) coated liposome (AL) was reported as an effective PTT agent with good biocompatibility and excretory property. However, exposed Au components on liposomes can cause instability in vivo and difficulty in further functionalization.

resultsHerein, we developed a theranostic dual-layered nanomaterial by adding liposomal layer to AL (LAL), followed by attaching polyethylene glycol (PEG) and radiolabeling. Functionalization with PEG improves the in vivo stability of LAL, and radioisotope labeling enables in vivo imaging of LAL. Functionalized LAL is stable in physiological conditions, and

conclusionBased on these high stability, in vivo imaging ability, and tumor targeting efficiency, LAL could be a promising theranostic PTT agent.

Indexed as

Drug Delivery SystemsNanostructuresAnimalsCell Line, TumorCell SurvivalFemaleGoldLiposomesMiceMice, Inbred BALB CMice, NudeNeoplasmsPhotothermal TherapyPolyethylene GlycolsPositron-Emission TomographyPrecision MedicineGoldLiposomesPolyethylene GlycolsAu-liposomeDouble-layered liposomeHyperthermiaPhotothermal therapyTheranostic

Identifiers

PMID34481489
PMCPMC8418714

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.