Evidence map›Paper›PMID 34481347›Full record

ArticleJournal of inorganic biochemistry2021

NRVS investigation of ascorbate peroxidase compound II: Observation of Iron(IV)oxo stretching.

Aaron P Ledray, Kaustuv Mittra, Michael T Green

Abstract read
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In one paragraph

Article in Journal of inorganic biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Stabilization of the Ferryl═Oxoheme Form ofJournal of the American Chemical Society · 2025
    Article
  2. Article
  3. Aspartate or arginine? Validated redox state X-ray structures elucidate mechanistic subtleties of FeJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aaron P LedrayDepartment of Chemistry, University of California, Irvine, CA 92697, USA; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Kaustuv MittraDepartment of Chemistry, University of California, Irvine, CA 92697, USA; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Michael T GreenDepartment of Chemistry, University of California, Irvine, CA 92697, USA; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA. Electronic address: professor_green@me.com.

Funding

Thermodynamic, Electronic, Structural, and Kinetic Characterizations of Cytochrome P450 Compounds I & IIR01GM101390 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MICHAEL T. GREEN · 2012 to 2026
$3.0M
NIGMS NIH HHS R01 GM101390
6 · The paper itself

Abstract

The protonation state of ascorbate peroxidase compound II (APX-II) has been a subject of debate. A combined X-ray/neutron crystallographic study reported that APX-II is best described as an iron(IV)hydroxide species with an FeO distance of 1.88 Å (Kwon, et al. Nat Commun2016, 7, 13,445), while X-ray absorption spectroscopy (XAS) experiments (utilizing extended X-ray absorption fine structure (EXAFS) and pre-edge analyses) indicate APX-II is an authentic iron(IV)oxo species with an FeO distance 1.68 Å (Ledray, et al. Journal of the American Chemical Society2020,142, 20,419). Previous debates concerning ferryl protonation states have been resolved through the application of Badger's rule, which correlates FeO bond distances with FeO vibrational frequencies. To obtain the required vibrational data, we have collected Nuclear Resonance Vibrational Spectroscopy (NRVS) data for APX-II. We observe a broad vibrational feature in the range associated with iron(IV)oxo stretching (700-800 cm

Indexed as

Ascorbate PeroxidasesCrystallography, X-RayFerric CompoundsHydrogen BondingHydroxidesIronMagnetic Resonance SpectroscopyMolecular StructureOxygenProtonsSpectrum Analysis, RamanX-Ray Absorption SpectroscopyAscorbate PeroxidasesFerric Compoundsferric hydroxideferryl ironhydroxide ionHydroxidesIronOxygenProtons

Identifiers

PMID34481347
PMCPMC11890179

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.