Evidence map›Paper›PMID 34481089›Full record

SynthesisJournal of sport and health science2022

Immediate effect of high-intensity exercise on brain-derived neurotrophic factor in healthy young adults: A systematic review and meta-analysis.

Rubén Fernández-Rodríguez, Celia Álvarez-Bueno, Isabel A Martínez-Ortega, Vicente Martínez-Vizcaíno, Arthur Eumann Mesas, Blanca Notario-Pacheco

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of sport and health science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rubén Fernández-RodríguezHealth and Social Research Center, Universidad de Castilla-La Mancha, Cuenca 16071, Spain.
Celia Álvarez-BuenoHealth and Social Research Center, Universidad de Castilla-La Mancha, Cuenca 16071, Spain; Universidad Politécnica y Artística del Paraguay, Asunción 2024, Paraguay. Electronic address: Celia.AlvarezBueno@uclm.es.
Isabel A Martínez-OrtegaHealth and Social Research Center, Universidad de Castilla-La Mancha, Cuenca 16071, Spain.
Vicente Martínez-VizcaínoHealth and Social Research Center, Universidad de Castilla-La Mancha, Cuenca 16071, Spain; Faculty of Medicine, Universidad Autónoma de Chile, Talca 3460000, Chile.
Arthur Eumann MesasHealth and Social Research Center, Universidad de Castilla-La Mancha, Cuenca 16071, Spain; Postgraduate Program in Public Health, Universidad Estadual de Londrina, Londrina 86051-990, Brazil.
Blanca Notario-PachecoHealth and Social Research Center, Universidad de Castilla-La Mancha, Cuenca 16071, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough brain-derived neurotrophic factor (BDNF) has been identified as a molecular biomarker of the neurophysiological effects induced by exercise, the acute effects of high-intensity exercise (HIE) on BDNF levels are inconclusive. This study aims to estimate the immediate effects of HIE on BDNF levels in healthy young adults.

methodsA systematic search was conducted in the MEDLINE, Scopus, Cochrane CENTRAL, and SPORTDiscuss databases up to December 2020. Randomized controlled trials (RCTs) and non-RCTs reporting pre-post changes in serum or plasma BDNF after an acute intervention of HIE compared to a control condition were included. Pooled effect sizes (p-ESs) and 95% confidence intervals (95%CIs) were calculated for RCTs using a random effects model with Stata/SE (Version 15.0; StataCorp., College Station, TX, USA). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. PROPERO registration number: CRD42020221047.

resultsA total of 22 studies with 552 individuals (age range: 20-31 years; 59.1% male) were included. The meta-analysis included 10 RCTs that reported valid outcome data. Higher BDNF levels were observed when HIE interventions were compared with non-exercise (p-ES = 0.55, 95%CI: 0.12-0.98; I

conclusionIn comparison to non-exercise or light-intensity exercises, an immediate increase in BDNF levels may occur when young adults perform HIE. Given the benefits obtained maximizing circulating BDNF when performing HIE and its potential effects on brain health, our findings suggest that HIE could be recommended by clinicians as a useful exercise strategy to healthy adults.

Indexed as

Brain-Derived Neurotrophic FactorExerciseAdultFemaleHealth StatusHumansMaleYoung AdultBrain-Derived Neurotrophic FactorCognitionExerciseNeurogenesisNeuroplasticity

Identifiers

PMID34481089
PMCPMC9189701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.