Evidence map›Paper›PMID 34480768›Full record

ArticleMagnetic resonance in medicine2022

Rapid simultaneous acquisition of macromolecular tissue volume, susceptibility, and relaxometry maps.

Fang Frank Yu, Susie Yi Huang, Ashwin Kumar, Thomas Witzel, Congyu Liao, Tanguy Duval, Julien Cohen-Adad, Berkin Bilgic

Erratum issuedAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Ultra-short TMagnetic resonance in medicine · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Fang Frank YuDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-9913-1331
Susie Yi HuangDepartment of Radiology, Harvard Medical School, Boston, Massachusetts, USA.
Ashwin KumarVanderbilt University, Nashville, Tennessee, USA.
Thomas WitzelQ Bio, Inc., Redwood City, California, USA.
Congyu LiaoRadiological Sciences Laboratory, Stanford Medicine, Stanford, California, USA.ORCID 0000-0003-2270-276X
Tanguy DuvalInstitute of Biomedical Engineering, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada.
Julien Cohen-AdadInstitute of Biomedical Engineering, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada.
Berkin BilgicDepartment of Radiology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9080-7865

Funding

CONNECTOME 2.0: DEVELOPING THE NEXT GENERATION HUMAN MRI SCANNER FOR BRIDGING STUDIES OF THE MICRO-, MESO- AND MACRO-CONNECTOMEU01EB026996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BASSER, PETER J., HUANG, SUSIE YI · 2018 to 2022
$14.2M
MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNERU01EB025162 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI FEINBERG, DAVID ALAN, LIU, CHUNLEI · 2017 to 2021
$13.4M
Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2020 to 2026
$10.9M
MRI technology for restoring brain image quality for pediatric patients with metallic orthodontic hardwareR01EB028797 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Berkin Bilgic, Jason P Stockmann · 2020 to 2026
$3.0M
Toward a Validated in Vivo Imaging Marker of Axonal Damage Predictive of Progressive Disability in Multiple SclerosisR01NS118187 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2021 to 2025
$2.8M
Characterizing axonal damage in multiple sclerosis using TractCaliber MRIK23NS096056 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2016 to 2020
$877k
Exploring the Relationship Between Tau Deposition and Neurovascular Health in Alzheimer's DiseaseR21AG067562 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI, YEN, YI-FEN · 2020 to 2020
$462k
NIA NIH HHS R21 AG067562NIBIB NIH HHS P41 EB030006NIBIB NIH HHS R01 EB028797NIBIB NIH HHS U01 EB025162NIBIB NIH HHS U01 EB026996NINDS NIH HHS K23 NS096056NINDS NIH HHS R01 NS118187
6 · The paper itself

Abstract

purposeA major obstacle to the clinical implementation of quantitative MR is the lengthy acquisition time required to derive multi-contrast parametric maps. We sought to reduce the acquisition time for QSM and macromolecular tissue volume by acquiring both contrasts simultaneously by leveraging their redundancies. The joint virtual coil concept with GRAPPA (JVC-GRAPPA) was applied to reduce acquisition time further.

methodsThree adult volunteers were imaged on a 3 Tesla scanner using a multi-echo 3D GRE sequence acquired at 3 head orientations. Macromolecular tissue volume, QSM,

resultsSubject 1's multi-orientation and single-orientation macromolecular tissue volume maps were not significantly different based on RMSE. For subject 2, the retrospectively undersampled JVC-GRAPPA and GRAPPA generated similar results as fully sampled data. This approach was validated with the prospectively undersampled images in subject 3. Using QSM,

conclusionWe have developed a novel strategy to simultaneously acquire data for the reconstruction of 5 intrinsically coregistered 1-mm isotropic resolution multi-parametric maps, with a scan time of 6 min using JVC-GRAPPA.

Indexed as

Image Processing, Computer-AssistedMagnetic Resonance ImagingBrainHumansProspective StudiesRetrospective Studiesacceleration methodsmulti-parametric imagingmyelin sensitive imagingneuroimagingquantitative susceptibility mapping

Identifiers

PMID34480768
PMCPMC8627440

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.