ArticleMagnetic resonance in medicine2022
Contribution of blood to nuclear Overhauser effect at -1.6 ppm.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 13 citations in OpenAlex.
- Quantum magnetization exchange through transient hydrogen bond matrix defines magnetic resonance signal relaxation and anisotropy in central nervous system.Scientific reports · 2025Article
- Nuclear Overhauser enhancement imaging at -1.6 ppm in rat brain at 4.7T.Magnetic resonance in medicine · 2024Article
- Validation of the presence of fast exchanging amine CEST effect at low saturation powers and its influence on the quantification of APT.Magnetic resonance in medicine · 2023Article
- Evaluation of contributors to amide proton transfer-weighted imaging and nuclear Overhauser enhancement-weighted imaging contrast in tumors at a high magnetic field.Magnetic resonance in medicine · 2023Article
- Assignment of molecular origins of NOE signal at -3.5 ppm in the brain.Magnetic resonance in medicine · 2023Article
- NOE-weighted imaging in tumors using low-duty-cycle 2π-CEST.Magnetic resonance in medicine · 2023Article
- Noninvasively differentiating acute and chronic nephropathies via multiparametric urea-CEST, nuclear Overhauser enhancement-CEST, and quantitative magnetization transfer MRI.Magnetic resonance in medicine · 2023Article
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5 authors at 1 institution in 1 country.
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Abstract
purposeA relayed nuclear Overhauser enhancement (rNOE) saturation transfer effect at around -1.6 ppm from water, termed NOE(-1.6), was previously reported in rat and human brain, and some publications suggest that it may be related to blood. Here, we studied whether the NOE(-1.6) arises from blood through in vivo and ex vivo experiments.
methodsTo evaluate the contribution from in vivo blood to NOE(-1.6), intravascular signals in rat brain were suppressed by two approaches: (1) signal acquisition with a diffusion-weighting of b = 400 s/mm
resultsThere are no significant variations in the fitted in vivo NOE(-1.6) signals when measured with or without diffusion-weighting, but significant signal decease does occur after injection of MION. The NOE(-1.6) signal from ex vivo blood is weaker than that from in vivo tissues.
conclusionConsidering the relatively small volume of blood in brain, the in vivo experiments with diffusion weighting and the ex vivo experiments both suggest that the NOE(-1.6) is not mainly from blood. The mechanism for the in vivo experiments with MION are less clear. MION not only suppresses MR signals from intravascular space, but changes the susceptibility in the perivascular space. This result suggests that although the NOE(-1.6) is not mainly from blood, it may be vasculature dependent.
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