ArticleThe New phytologist2021
Unraveling the role of MADS transcription factor complexes in apple tree dormancy.
Article in The New phytologist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- From chill to bloom: seasonal coordination of reproductive development in peach and temperate fruit trees.Journal of experimental botany · 2026Review
- Article
- Multi-omics analysis of the regulatory network in winter buds of 'Cabernet Sauvignon' grapevine from dormancy to bud break.Plant biotechnology journal · 2025Article
- MADS-domain transcription factor AGAMOUS LIKE-9 participates in the gibberellin pathway to promote bud dormancy release of tree peony.Horticulture research · 2025Article
- Modeling budbreak precocity in grapevine: insights from comparative gene expression analysis in single-node cuttings.Planta · 2025Article
- Regulatory role ofHorticulture research · 2024Article
- Identification and functional analysis of the LEAFY gene in longan flower induction.BMC genomics · 2024Article
- Regulatory frameworks involved in the floral induction, formation and developmental programming of woody horticultural plants: a case study on blueberries.Frontiers in plant science · 2024Review
- Target enrichment sequencing coupled with GWAS identifiesFrontiers in plant science · 2024Article
- Functional evidence on the involvement of theFrontiers in plant science · 2024Article
- Age-dependent seasonal growth cessation inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- MADS-box protein PpDAM6 regulates chilling requirement-mediated dormancy and bud break in peach.Plant physiology · 2023Article
- The bZIP transcription factor AREB3 mediates FT signalling and floral transition at the Arabidopsis shoot apical meristem.PLoS genetics · 2023Article
- Advancing tree genomics to future proof next generation orchard production.Frontiers in plant science · 2023Review
- Molecular mechanisms of flowering phenology in trees.Forestry research · 2023Review
- Transcriptomics Analysis Reveals a Putative Role for Hormone Signaling and MADS-Box Genes in Mature Chestnut Shoots Rooting Recalcitrance.Plants (Basel, Switzerland) · 2022Article
- Evolutionary origin and functional specialization of Dormancy-Associated MADS box (DAM) proteins in perennial crops.BMC plant biology · 2022Article
- Genome-Wide Analyses of MADS-Box Genes inPlants (Basel, Switzerland) · 2022Article
- Erratum: Time-Resolved Analysis of Candidate Gene Expression and Ambient Temperature During Bud Dormancy in Apple.Frontiers in plant science · 2022Article
- CisCross: A gene list enrichment analysis to predict upstream regulators inFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A group of MADS transcription factors (TFs) are believed to control temperature-mediated bud dormancy. These TFs, called DORMANCY-ASSOCIATED MADS-BOX (DAM), are encoded by genes similar to SHORT VEGETATIVE PHASE (SVP) from Arabidopsis. MADS proteins form transcriptional complexes whose combinatory composition defines their molecular function. However, how MADS multimeric complexes control the dormancy cycle in trees is unclear. Apple MdDAM and other dormancy-related MADS proteins form complexes with MdSVPa, which is essential for the ability of transcriptional complexes to bind to DNA. Sequential DNA-affinity purification sequencing (seq-DAP-seq) was performed to identify the genome-wide binding sites of apple MADS TF complexes. Target genes associated with the binding sites were identified by combining seq-DAP-seq data with transcriptomics datasets obtained using a glucocorticoid receptor fusion system, and RNA-seq data related to apple dormancy. We describe a gene regulatory network (GRN) formed by MdSVPa-containing complexes, which regulate the dormancy cycle in response to environmental cues and hormonal signaling pathways. Additionally, novel molecular evidence regarding the evolutionary functional segregation between DAM and SVP proteins in the Rosaceae is presented. MdSVPa sequentially forms complexes with the MADS TFs that predominate at each dormancy phase, altering its DNA-binding specificity and, therefore, the transcriptional regulation of its target genes.
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