Evidence map›Paper›PMID 34480651›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2021

In vitro antiplasmodial activity, targeted LC-MS metabolite profiling, and identification of major natural products in the bioactive extracts of Palicourea and Psychotria species from the Amazonia and Atlantic Forest biomes, Brazil.

Douglas Costa Gontijo, Maria Fernanda Alves do Nascimento, Hugo Vianna Silva Rody, Rodrigo Andrade Magalhães, Luciano Ferreira Margalho, Geraldo Célio Brandão, Alaíde Braga de Oliveira

Abstract read
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In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Douglas Costa GontijoDepartamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, MG, 31270-901, Brazil.ORCID 0000-0002-7759-9694
Maria Fernanda Alves do NascimentoDepartamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, MG, 31270-901, Brazil.ORCID 0000-0003-0147-6011
Hugo Vianna Silva RodyEscola Superior de Agricultura "Luiz de Queiroz", Departamento de Genética, Universidade de São Paulo, Av. Pádua Dias, 11, Piracicaba, SP, 13418-900, Brazil.ORCID 0000-0003-3762-2092
Rodrigo Andrade MagalhãesDepartamento de Botânica, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, MG, 31270-901, Brazil.ORCID 0000-0001-5439-5704
Luciano Ferreira MargalhoInstituto Federal do Pará, Av. Arterial 5-B, s/n, Icuí-Guajará, Ananindeua, PA, 67140-000, Brazil.ORCID 0000-0002-4550-6166
Geraldo Célio BrandãoEscola de Farmácia, Universidade Federal de Ouro Preto, Morro Do Cruzeiro, s/n, Ouro Prêto, MG, 35400-000, Brazil.ORCID 0000-0002-7330-051X
Alaíde Braga de OliveiraDepartamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, MG, 31270-901, Brazil. alaidebragaoliveira@gmail.com.ORCID 0000-0002-0374-8909
Universidade Federal de Minas Gerais · BRInstituto Federal do Paraná · BRUniversidade de São Paulo · BRUniversidade Federal de Ouro Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA great variety of bioactive natural products has been reported for different Palicourea and Psychotria species (Rubiaceae). However, few of them as well as few of species of these botanical genera have been evaluated for antiplasmodial activity.

objectiveTo assess the antiplasmodial activity of 24 extracts from Palicourea and Psychotria genera, along with the targeted LC-MS metabolite profiling, as well as identification of the main metabolites in the bioactive extracts.

methodsTwenty four ethanol and acid-base extracts from Palicourea and Psychotria genera collected in the Amazonia and Atlantic Forest, Brazil, were evaluated against chloroquine-resistant Plasmodium falciparum W2 strain by PfLDH. The metabolite profiling and putative identification of metabolites from bioactive extracts were determined by LC-DAD-ESI-MS and LC-HRMS, respectively.

resultsThe ethanol extracts disclosed low antiplasmodial activity (% GI < 50%). High antiplasmodial effect was observed for the acid-base extracts from Psychotria apoda and Psychotria colorata with 100% inhibition of parasite growth inhibition. Fragment ions related to pyrrolidinoindoline alkaloids were observed by LC-DAD-ESI-MS mainly in the most bioactive extracts. The results of the in vitro screening associated with the LC-DAD-ESI-MS and LC-HRMS

conclusionThe present results point to Palicourea and Psychotria species as sources of new antimalarial hits.

Indexed as

AlkaloidsAntimalarialsBiological ProductsPsychotriaRubiaceaeBrazilChromatography, LiquidEcosystemEthanolForestsPlant ExtractsPlant LeavesTandem Mass SpectrometryAlkaloidsAntimalarialsBiological ProductsEthanolPlant ExtractsAlkaloidsBioactivityPhenolicsPhytochemistryPsychotrieae allianceRubiaceae

Identifiers

PMID34480651
OpenAlexW3197205398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.