Evidence map›Paper›PMID 34480645›Full record

SynthesisClinical oral investigations2021

Systematic review and meta-analysis of diagnostic studies of proximal surface caries.

Mila Janjic Rankovic, Svetlana Kapor, Yegane Khazaei, Alexander Crispin, Ina Schüler, Felix Krause, Kim Ekstrand, Stavroula Michou, Florin Eggmann, Adrian Lussi and 3 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mila Janjic RankovicDepartment of Orthodontics and Dentofacial Orthopedics, University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
Svetlana KaporDepartment of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
Yegane KhazaeiDepartment of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
Alexander CrispinInstitute of Medical Biometry and Epidemiology, Ludwig-Maximilians University of Munich, Munich, Germany.
Ina SchülerDepartment of Orthodontics, Section of Preventive and Paediatric Dentistry, University Hospital, Jena, Germany.
Felix KrauseClinic for Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital RWTH Aachen, Aachen, Germany.
Kim EkstrandDepartment of Odontology, University of Copenhagen, Copenhagen, Denmark.
Stavroula MichouDepartment of Odontology, University of Copenhagen, Copenhagen, Denmark.
Florin EggmannClinic of Periodontology, Endodontology and Cariology, University Centre for Dental Medicine Basel, University of Basel, Basel, Switzerland.
Adrian LussiDepartment of Operative Dentistry and Periodontology, Faculty of Dentistry, University Medical Centre, Freiburg, Germany.
Marie-Charlotte HuysmansDepartment of Dentistry, Radboud University Medical Centre, Nijmegen, The Netherlands.
Klaus NeuhausClinic of Periodontology, Endodontology and Cariology, University Centre for Dental Medicine Basel, University of Basel, Basel, Switzerland.
Jan KühnischDepartment of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians University Munich, Munich, Germany. jkuehn@dent.med.uni-muenchen.de.ORCID http://orcid.org/0000-0003-4063-2291

Funding

Deutsche Forschungsgemeinschaft (DE) SCHU-3217/1-1
6 · The paper itself

Abstract

aimThis systematic review and meta-analysis aimed to assess the diagnostic accuracy and reliability of commonly used caries detection methods for proximal caries diagnostics. Visual examination (VE), bitewing radiography (BWR), laser fluorescence (LF), and fibre-optic transillumination (FOTI) were considered in detail. MATERIAL AND

methodsPRISMA guidelines for the reporting of systematic reviews and meta-analyses were applied. The mnemonic PIRDS (problem, index test, reference test, diagnostic and study type) concept was used to guide the literature search. Next, studies that met the inclusion criteria were stepwise selected and evaluated for their quality with a risk of bias (RoB) assessment tool. Studies with low/moderate bias and sufficient reporting were considered for meta-analysis. The pooled sensitivity (SE), specificity (SP), diagnostic odds ratio (DOR), and area under the ROC curve (AUC) were calculated.

resultsFrom 129 studies meeting the selection criteria, 31 in vitro studies and five clinical studies were finally included in the meta-analysis. The AUC values for in vitro VE amounted to 0.84 (caries detection) and 0.85 (dentin caries detection). BWR ranged in vitro from 0.55 to 0.82 (caries detection) and 0.81-0.92 (dentin caries detection). LF showed higher AUC values for overall caries detection (0.91) and dentin caries detection (0.83) than did other methods. Clinical data are limited.

conclusionThe number of diagnostic studies with low/moderate RoB was found to be low and indicates a need for high-quality, well-designed caries diagnostic studies. CLINICAL RELEVANCE: BWR and LF showed good diagnostic performance on proximal surfaces. However, because of the low number of includable clinical studies, these data should be interpreted with caution.

Indexed as

Dental Caries SusceptibilityDiagnostic Tests, RoutineReproducibility of ResultsSensitivity and SpecificityTransilluminationApproximal cariesBitewing radiographyCaries detectionCaries diagnosticsDiagnostic accuracyDiagnostic performanceFibre-optic transilluminationInterproximal cariesLaser fluorescence measurementsMeta-analysisProximal cariesSensitivitySpecificitySystematic reviewVisual examination

Identifiers

PMID34480645
PMCPMC8531083

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.