ArticleJournal of clinical laboratory analysis2021
Prenatal diagnosis of thalassemia in 695 pedigrees from southeastern China: a 10-year follow-up study.
Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 15 citations in OpenAlex.
- The shifting global thalassemia burden and lessons from Chineseintegrated control strategy.iScience · 2026Article
- Third-generation sequencing technology in the prevention and control of thalassemia: Applications and advances.The Journal of international medical research · 2026Review
- Machine learning and AI-Assisted red blood cell morphology analysis for effective thalassemia screening.Annals of hematology · 2026Article
- Prevention and control of thalassemia in Guangdong Province, Southern China: insights from an 11-year retrospective study.Annals of medicine · 2025Article
- Genotype-phenotype correlation analysis of patients with thalassemia in quanzhou city, southeast of China.Heliyon · 2024Article
- The temporal trends of prevalence and years lived with disability of anaemia in China, Japan, and South Korea, from 1990 to 2021: Results from the Global Burden of Disease Study 2021.Journal of global health · 2024Article
- Current Status of Molecular Diagnosis of Hereditary Hemolytic Anemia in Korea.Journal of Korean medical science · 2024Review
- Molecular Characterization of α- and β-Thalassemia Among Children Less Than 18 Years Old in Guizhou, China.Journal of clinical laboratory analysis · 2024Article
- Molecular patterns of alpha-thalassemia in the kingdom of Saudi Arabia: identification of prevalent genotypes and regions with high incidence.Thrombosis journal · 2023Article
- Article
- Molecular prevalence ofFrontiers in genetics · 2022Article
- Molecular Spectrum, Ethnic and Geographical Distribution of Thalassemia in the Southern Area of Hainan, China.Frontiers in pediatrics · 2022Article
- Prenatal diagnosis of thalassemia in 695 pedigrees from southeastern China: a 10-year follow-up study.Journal of clinical laboratory analysis · 2021Article
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7 authors at 1 institution in 1 country.
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Abstract
Thalassaemia is highly prevalent in southeastern China. This 10-year follow-up study aimed to characterize the genotype and karyotype of thalassaemia in fetal samples derived from thalassemia carriers in Fujian province, southeastern China. A total of 476 prenatal samples from 472 couples carrying α-thalassaemia traits and 224 samples from 223 couples carrying β-thalassaemia traits were collected for STR analysis, detection of thalassemia genotypes and karyotyping. The common deletional α-thalassemias and rare thalassemia genotypes were detected using Gap-PCR assay, and the common β-globin gene mutations were detected using PCR-RDB assay. We detected 43.49% prevalence of α-thalassaemia minor, 26.05% prevalence of α-thalassaemia intermediate and major and 1.89% prevalence of rare form among the 476 prenatal samples from couples with α-thalassaemia, and 85 fetuses with β-thalassemia heterozygote, 16 with homozygote and 21 with double heterozygote, and a rare β
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