Evidence map›Paper›PMID 34480422›Full record

ArticleESC heart failure2021

The genomics of heart failure: design and rationale of the HERMES consortium.

R Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V Holmes and 165 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Identification of disease-specific pathways and modifiers in phospholamban R14del cardiomyopathy: rationale, design and baseline characteristics of DECIPHER-PLN cohort.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2025
    Article
  6. Review
  7. Article
  8. Article
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  11. Article
  12. Proteomic Associations of Adverse Outcomes in Human Heart Failure.Journal of the American Heart Association · 2024
    Article
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  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

175 authors at 20 institutions in 18 countries.

R Thomas LumbersInstitute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Sonia ShahInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Honghuang LinSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Tomasz CzubaDepartment of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
Albert HenryInstitute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Daniel I SwerdlowInstitute of Cardiovascular Science, University College London, London, UK.
Anders MälarstigPfizer Worldwide Research & Development, Cambridge, MA, USA.
Charlotte AnderssonNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Michael V HolmesMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
Johan ÄrnlövDepartment of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
Per SvenssonDepartment of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
Harry HemingwayInstitute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Neneh SallahInstitute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Peter AlmgrenDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Krishna G AragamProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Geraldine AsselinMontreal Heart Institute, Montreal, Quebec, Canada.
Joshua D BackmanRegeneron Genetics Center, Tarrytown, NY, USA.
Mary L BiggsDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Heather L BloomDivision of Cardiology, Department of Medicine, Emory University Medical Center, Atlanta, GA, USA.
Eric BoersmaErasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Jeffrey BrandimartoPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Hans-Peter Brunner-La RoccaMaastricht University Medical Center, Maastricht, The Netherlands.
David J CareyDepartment of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.
Mark D ChaffinCardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Olympe ChazaraCentre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Xing ChenPfizer Worldwide Research & Development, Cambridge, MA, USA.
Xu ChenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jonathan H ChungRegeneron Genetics Center, Tarrytown, NY, USA.
William ChutkowNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
John G F ClelandRobertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
James P CookDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Simon de DenusMontreal Heart Institute, Montreal, Quebec, Canada.
Abbas DehghanDepartment of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.
Graciela E DelgadoVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.
Spiros DenaxasInstitute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Alexander S DoneyDivision of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Marcus DörrDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Samuel C DudleyCardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Gunnar EngströmDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Tõnu EskoProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ghazaleh FatemifarInstitute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Stephan B FelixDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Chris FinanInstitute of Cardiovascular Science, University College London, London, UK.
Ian FordRobertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
Francoise FougerousseTranslational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France.
René FouodjioMontreal Heart Institute, Montreal, Quebec, Canada.
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Sahar GhasemiDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
John S GottdienerDepartment of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Stefan GrossDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Daníel F GuðbjartssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Hongsheng GuiCenter for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
Rebecca GutmannDivision of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Christopher M HaggertyDepartment of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Åsa K HedmanCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
Anna HelgadottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Hans HillegeDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Craig L HydePfizer Worldwide Research & Development, Cambridge, MA, USA.
Jaison JacobNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Frederick KamanuCardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Isabella KardysErasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Maryam KavousiDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Kay-Tee KhawDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Marcus E KleberVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.
Lars KøberDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Andrea KoekemoerDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Bill KrausDuke Molecular Physiology Institute, Durham, NC, USA.
Karoline KuchenbaeckerUCL Genetics Institute, University College London, London, UK.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Cecilia M LindgrenProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Barry LondonDivision of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.
Luca A LottaMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Ruth C LoveringInstitute of Cardiovascular Science, University College London, London, UK.
Jian'an LuanMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Patrik MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Anubha MahajanGenentech Inc., San Francisco, CA, USA.
Douglas MannCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Kenneth B MarguliesPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nicholas A MarstonTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Winfried MärzVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.
John J V McMurrayBHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Olle MelanderDepartment of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden.
Giorgio MelloniCardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ify R MordiDivision of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Michael P MorleyPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Andrew D MorrisUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Andrew P MorrisDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Michael W NaglePfizer Worldwide Research & Development, Cambridge, MA, USA.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Christopher Newton-ChehCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Alexander NiessnerDepartment of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
Teemu NiiranenFinnish Institute for Health and Welfare, Helsinki, Finland.
Christoph NowakDepartment of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
Michelle L O'DonoghueTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Anjali T OwensPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Colin N A PalmerDivision of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Guillaume ParéDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Markus PerolaNational Institute for Health and Welfare, Helsinki, Finland.
Louis-Philippe Lemieux PerreaultMontreal Heart Institute, Montreal, Quebec, Canada.
Eliana Portilla-FernandezDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Simon P R RomaineDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Carolina RoselliDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Christian T RuffTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marc S SabatineTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Perttu SaloFinnish Institute for Health and Welfare, Helsinki, Finland.
Veikko SalomaaFinnish Institute for Health and Welfare, Helsinki, Finland.
Jessica van SettenDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Alaa A ShalabyDivision of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA.
Diane T SmelserDepartment of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.
Nicholas L SmithKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.
Kari StefanssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Steen StenderDepartment of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte, Denmark.
David J StottInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Garðar SveinbjörnssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Mari-Liis TammesooEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Jean-Claude TardifMontreal Heart Institute, Montreal, Quebec, Canada.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Maris Teder-LavingEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Alexander TeumerDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Guðmundur ThorgeirssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Unnur ThorsteinsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Christian Torp-PedersenDepartment of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Danny TuckwellNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
Benoit TylTranslational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France.
Andre G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Felix VauraFinnish Institute for Health and Welfare, Helsinki, Finland.
Abirami VeluchamyDivision of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Peter M VisscherInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Uwe VölkerDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Adriaan A VoorsDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Xiaosong WangNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Peter E WeekeDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Raul WeissDivision of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA.
Harvey D WhiteGreen Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.
Kerri L WigginsDepartment of Medicine, University of Washington, Seattle, WA, USA.
Heming XingNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
Jian YangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Yifan YangPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Laura M Yerges-ArmstrongHuman Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Bing YuHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Faiez ZannadCHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, Université de Lorraine, Nancy, France.
Faye ZhaoNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
Regeneron Genetics CenterRegeneron Genetics Center, Tarrytown, NY, USA.
Jemma B WilkPfizer Worldwide Research & Development, Cambridge, MA, USA.
Hilma HolmdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Naveed SattarBHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Steven A LubitzProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
David E LanfearCenter for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
Svati ShahDuke Molecular Physiology Institute, Durham, NC, USA.
Michael E DunnRegeneron Pharmaceuticals, Cardiovascular Research, Tarrytown, NY, USA.
Quinn S WellsDivision of Cardiovascular Medicine and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN, USA.
Folkert W AsselbergsHealth Data Research UK London, University College London, London, UK.
Aroon D HingoraniBHF Research Accelerator, University College London, London, UK.
Marie-Pierre DubéMontreal Heart Institute, Montreal, Quebec, Canada.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Chim C LangDivision of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Thomas P CappolaPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Patrick T EllinorCardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ramachandran S VasanNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
J Gustav SmithDepartment of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
Karolinska Institutet · SEBrigham and Women's Hospital · USErasmus MC · NLMontreal Heart Institute · CAUniversity of Pennsylvania · USUniversity College London · GBAmgen (Canada) · CAUniversity of Washington · USBroad Institute · USdeCODE Genetics (Iceland) · ISFinnish Institute for Health and Welfare · FIGeisinger Medical Center · USGlenfield Hospital · GBMassachusetts General Hospital · USMRC Epidemiology Unit · GBNinewells Hospital · GBNovartis (China) · CNPfizer (United States) · USRegeneron (United States) · USSkåne University Hospital · SE

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Heart Failure Clinical Research Network Coordinating CenterU10HL084904 · NHLBI · DUKE UNIVERSITY · PI ANSTROM, KEVIN J, HERNANDEZ, ADRIAN · 2012 to 2018
$38.0M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8M
Utilizing the Phenomics of IBD to Enhance Gene DiscoveryU01DK062413 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Dermot Patrick McGovern · 2002 to 2026
$12.2M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
MTSS1 in Myocardial DiseaseR01HL141232 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI THOMAS P. CAPPOLA, Scott Michael Damrauer · 2019 to 2026
$4.7M
Mayo Heart Failure Regional Clinical CenterU10HL110262 · NHLBI · MAYO CLINIC ROCHESTER · PI REDFIELD, MARGARET M · 2012 to 2018
$3.6M
Heart Failure Clinical Research Network Regional Clinical Center (U10)U10HL110312 · NHLBI · DUKE UNIVERSITY · PI FELKER, GARY M · 2012 to 2018
$3.5M
SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial)U10HL110309 · NHLBI · WASHINGTON UNIVERSITY · PI DAVILA-ROMAN, VICTOR G., MANN, DOUGLAS L · 2012 to 2018
$3.5M
Harvard Regional Clinical Center of the NHLBI Heart Failure NetworkU10HL110337 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI GIVERTZ, MICHAEL M, LEWIS, GREGORY DYER · 2012 to 2018
$3.5M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
British Heart Foundation RE/18/6/34217Department of HealthMedical Research Council G0902393Medical Research Council MC_PC_13041Medical Research Council MC_UU_00006/1Medical Research Council MR/K006584/1Medical Research Council MR/S003754/1NCATS NIH HHS UL1 TR001881NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K08 HL153950NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL141232NHLBI NIH HHS U10 HL084904NHLBI NIH HHS U10 HL110262NHLBI NIH HHS U10 HL110297NHLBI NIH HHS U10 HL110302NHLBI NIH HHS U10 HL110309NHLBI NIH HHS U10 HL110312NHLBI NIH HHS U10 HL110336NHLBI NIH HHS U10 HL110337NHLBI NIH HHS U10 HL110338NHLBI NIH HHS U10 HL110342NIDDK NIH HHS P30 DK063491NIDDK NIH HHS U01 DK062413
6 · The paper itself

Abstract

aimsThe HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. METHODS AND

resultsThe consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10

conclusionsHERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

Indexed as

Genome-Wide Association StudyHeart FailureAgedAged, 80 and overFemaleGenomicsHumansMaleMiddle AgedPrognosisAssociation studiesBiomarkersCardiomyopathyGeneticsHeart failure

Identifiers

PMID34480422
PMCPMC8712846
OpenAlexW3197649229

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