Evidence map›Paper›PMID 34480298›Full record

ArticleDrug delivery and translational research2022

Dispersion profile of a needle-free jet injection depends on the interfacial property of the medium.

Abdul Mohizin, Jung Kyung Kim

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Abdul MohizinDepartment of Mechanical Engineering, Graduate School, Kookmin University, Seoul, 02707, Republic of Korea.
Jung Kyung KimSchool of Mechanical Engineering and Department of Integrative Biomedical Science and Engineering, Graduate School, Kookmin University, Seoul, 02707, Republic of Korea. jkkim@kookmin.ac.kr.ORCID 0000-0002-4164-6655

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injections into or through the skin are common drug or vaccine administration routes, which can be achieved with conventional needles, microneedles, or needle-free jet injections (NFJI). Understanding the transport mechanism of these injected fluids is critical for the development of effective drug administration devices. NFJI devices are distinct from traditional injection techniques by their route and time scale, which relies on a propelled microjet with sufficient energy to penetrate the skin surface and deliver the drug into the targeted region. The injected fluid interacts with multiple skin tissue layers and interfaces, which implies that the corresponding injection profile is dependent on their mechanical properties. In this study, we address the lack of fundamental knowledge on the impact of these interfaces on the injection profiles of NFJI devices.

Indexed as

Drug Delivery SystemsSkinEquipment DesignInjections, JetPharmaceutical PreparationsPharmaceutical PreparationsGap/Loose junctionInjection depthJet injectionMicrojetNeedle-free injectionTight junctionTransdermal drug delivery

Identifiers

PMID34480298

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.