Evidence map›Paper›PMID 34480258›Full record

ArticleBrain imaging and behavior2022

Intravoxel incoherent motion diffusion-weighted imaging in the characterization of Alzheimer's disease.

Nengzhi Xia, Yanxuan Li, Yingnan Xue, Weikang Li, Zhenhua Zhang, Caiyun Wen, Jiance Li, Qiong Ye

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  3. Exploring the Mechanism of Postpartum Cognitive Dysfunction in a Preeclampsia Rat Model via Multimodal Imaging.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nengzhi XiaDepartment of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Yanxuan LiDepartment of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Yingnan XueDepartment of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Weikang LiDepartment of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Zhenhua ZhangDepartment of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Caiyun WenDepartment of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Jiance LiDepartment of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Qiong YeDepartment of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China. 94301699@qq.com.ORCID http://orcid.org/0000-0003-1028-3721
Wenzhou Medical University · CNChinese Academy of Sciences · CN

Funding

National Natural Science Foundation of China 81401544Natural Science Foundation of Zhejiang Province of China LQ14H180006research incubation project of the first affiliated hospital of wenzhou medical university FHF2019071Wenzhou Science and Technology Plan Project Y20150087Wenzhou Science and Technology Plan Project Y20160469
6 · The paper itself

Abstract

objectivesAlzheimer's disease (AD) is the most common type of dementia, and characterizing brain changes in AD is important for clinical diagnosis and prognosis. This study was designed to evaluate the classification performance of intravoxel incoherent motion (IVIM) diffusion-weighted imaging in differentiating between AD patients and normal control (NC) subjects and to explore its potential effectiveness as a neuroimaging biomarker.

methodsThirty-one patients with probable AD and twenty NC subjects were included in the prospective study. IVIM data were subjected to postprocessing, and parameters including the apparent diffusion coefficient (ADC), slow diffusion coefficient (D

resultsDiffusion MRI revealed significant region-specific differences that aided in differentiating AD patients from controls. Among the analyzed regions and parameters, the D

conclusionIVIM imaging is a promising method for the classification of AD and NC subjects, and IVIM parameters of precuneus and cerebellum might be effective biomarker for the diagnosis of AD.

Indexed as

Alzheimer DiseaseBiomarkersDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingMotionProspective StudiesReproducibility of ResultsBiomarkersAlzheimer’s diseaseCross-validationDiffusionIntravoxel incoherent motionPrecuneus

Identifiers

PMID34480258
OpenAlexW3198219724

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.