Evidence map›Paper›PMID 34480197›Full record

ArticleSouthern medical journal2021

Immune Checkpoint Inhibitor-Related Pulmonary Toxicity: A Comprehensive Review, Part II.

Hazim Bukamur, Akram Alkrekshi, Heather Katz, Mohamed Alsharedi, Yousef R Shweihat, Nancy J Munn

Open access · greenAbstract read
In one paragraph

Article in Southern medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hazim BukamurFrom the Departments of Pulmonary and Critical Care Medicine and Hematology and Oncology Medicine, Marshall University, Joan C. Edwards School of Medicine, the Huntington Veterans Administration Medical Center, Huntington, West Virginia, and the MetroHealth System Campus of Case Western Reserve University, Cleveland, Ohio.
Akram AlkrekshiFrom the Departments of Pulmonary and Critical Care Medicine and Hematology and Oncology Medicine, Marshall University, Joan C. Edwards School of Medicine, the Huntington Veterans Administration Medical Center, Huntington, West Virginia, and the MetroHealth System Campus of Case Western Reserve University, Cleveland, Ohio.
Heather KatzFrom the Departments of Pulmonary and Critical Care Medicine and Hematology and Oncology Medicine, Marshall University, Joan C. Edwards School of Medicine, the Huntington Veterans Administration Medical Center, Huntington, West Virginia, and the MetroHealth System Campus of Case Western Reserve University, Cleveland, Ohio.
Mohamed AlsharediFrom the Departments of Pulmonary and Critical Care Medicine and Hematology and Oncology Medicine, Marshall University, Joan C. Edwards School of Medicine, the Huntington Veterans Administration Medical Center, Huntington, West Virginia, and the MetroHealth System Campus of Case Western Reserve University, Cleveland, Ohio.
Yousef R ShweihatFrom the Departments of Pulmonary and Critical Care Medicine and Hematology and Oncology Medicine, Marshall University, Joan C. Edwards School of Medicine, the Huntington Veterans Administration Medical Center, Huntington, West Virginia, and the MetroHealth System Campus of Case Western Reserve University, Cleveland, Ohio.
Nancy J MunnFrom the Departments of Pulmonary and Critical Care Medicine and Hematology and Oncology Medicine, Marshall University, Joan C. Edwards School of Medicine, the Huntington Veterans Administration Medical Center, Huntington, West Virginia, and the MetroHealth System Campus of Case Western Reserve University, Cleveland, Ohio.
MetroHealth Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of immune checkpoint inhibitors (ICIs) has changed the treatment paradigm for cancer. The ICIs nivolumab, pembrolizumab, and cemiplimab target programmed cell death protein 1, and durvalumab, avelumab, and atezolizumab target programmed death ligand 1. Ipilimumab targets cytotoxic T lymphocyte-associated antigen-4. Used as monotherapy or in combination, they have shown remarkable efficacy in melanoma, lung cancer, and many other solid tumors, and indications continue to evolve. These checkpoint inhibitors are typically well tolerated; however, they may cause immune-mediated adverse effects, resulting in inflammation of any organ system. Pulmonary toxicity is vital to recognize, and it can be more challenging to diagnose in patients with lung cancer, given the nature of the disease course and treatment.

Indexed as

Antibodies, MonoclonalAntibodies, Monoclonal, HumanizedDrug-Related Side Effects and Adverse ReactionsHumansImmune Checkpoint InhibitorsLungAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedatezolizumabavelumabdurvalumabImmune Checkpoint Inhibitorspembrolizumab

Identifiers

PMID34480197
PMCPMC8389348
OpenAlexW3197209558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.