ArticleInternational journal of obesity (2005)2022
The genetics of testosterone contributes to "femaleness/maleness" of cardiometabolic traits and type 2 diabetes.
Article in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- The value of sex hormones and sex hormone-binding globulin in metabolic dysfunction-associated fatty liver disease among boys with obesity.Frontiers in endocrinology · 2025Article
- Correlation between fat-to-muscle mass ratio and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study.BMC geriatrics · 2024Article
- Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance.Nature communications · 2024Article
- The genetics of a "femaleness/maleness" score in cardiometabolic traits in the UK biobank.Scientific reports · 2023Article
- A Shifting Relationship Between Sex Hormone-Binding Globulin and Total Testosterone Across Puberty in Boys.The Journal of clinical endocrinology and metabolism · 2022Article
- Sex- and age-specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The genetic architecture of testosterone is highly distinct between sexes. Moreover, obesity is associated with higher testosterone in females but lower testosterone in males. Here, we ask whether male-specific testosterone variants are associated with a male pattern of obesity and type 2 diabetes (T2D) in females, and vice versa. In the UK Biobank, we conducted sex-specific genome-wide association studies and computed polygenic scores for total (PGS
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Registered trials
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