Evidence map›Paper›PMID 34480035›Full record

ArticleScientific reports2021

Changes in plasma C1q, apelin and adropin concentrations in older adults after descending and ascending stair walking intervention.

Trevor C Chen, Tsang-Hai Huang, Wei-Chin Tseng, Kuo-Wei Tseng, Chung-Chan Hsieh, Mei-Yen Chen, Tai-Ying Chou, Yuh-Chuan Huang, Hsin-Lian Chen, Kazunori Nosaka

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06574854 (Effects of Descending Stair Walking on Cardiometabolic Adaptations Among Obese, Untrained Women), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06574854 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Descending Stair Walking on Cardiometabolic Adaptations Among Obese, Untrained Women

TypeinterventionalSponsorUniversiti Sains MalaysiaRan2023 to 2025Enrolled24ConditionsObesityArmsDSW, ASW
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Trevor C ChenDepartment of Physical Education and Sport Sciences, National Taiwan Normal University, P.O. Box 97-71, Wenshan Wansheng, Taipei City, 11699, Taiwan. tcchen@ntnu.edu.tw.ORCID 0000-0001-8769-1833
Tsang-Hai HuangInstitute of Physical Education, Health and Recreation, National Cheng-Kung University, Tainan City, Taiwan.ORCID 0000-0002-7353-8560
Wei-Chin TsengDepartment of Exercise and Health Sciences, University of Taipei, Taipei City, Taiwan.
Kuo-Wei TsengDepartment of Exercise and Health Sciences, University of Taipei, Taipei City, Taiwan.
Chung-Chan HsiehDepartment of Physical Education and Sport Sciences, National Taiwan Normal University, P.O. Box 97-71, Wenshan Wansheng, Taipei City, 11699, Taiwan.
Mei-Yen ChenGraduate Institute of Sport, Leisure and Hospitality Management, National Taiwan Normal University, Taipei City, Taiwan.ORCID 0000-0002-3744-2684
Tai-Ying ChouDepartment of Athletic Performance, National Taiwan Normal University, Taipei City, Taiwan.
Yuh-Chuan HuangPhysical Education Office, Ming Chuan University, Taipei City, Taiwan.
Hsin-Lian ChenDepartment of Physical Education, Health and Recreation, National Chiayi University, Chaiyi County, Taiwan.
Kazunori NosakaCentre for Exercise and Sports Science Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.ORCID 0000-0001-7373-4994
National Taiwan Normal University · TWUniversity of Taipei · TWEdith Cowan University · AUMing Chuan University · TWNational Cheng Kung University · TWNational Chiayi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study compared changes in plasma complement component 1q (C1q), apelin and adropin concentrations in older obese women after descending (DSW) and ascending stair walking (ASW) training (n = 15/group) performed twice a week for 12 weeks, with gradual increases in exercise time from 5 to 60 min. Fasting blood samples were collected 3 days before the first and 4 days after the last training session. The improvements in the maximal voluntary isometric contraction (MVIC) strength of the knee extensors, functional physical fitness [e.g., 30-s chair stand (CS) performance], resting systolic blood pressure (SBP), insulin sensitivity [e.g., oral glucose tolerance test (OGTT)] and blood lipid profiles [e.g., total cholesterol (TC)] were greater (p < 0.05) in the DSW than ASW group. Plasma C1q decreased (- 51 ± 30%), and apelin (23 ± 15%) and adropin (127 ± 106%) increased (p ≤ .0.05) only after DSW. Significant (p ≤  0.01) partial correlations were found between the pre- to post-DSW changes in C1q, apelin or adropin and changes in outcome measures [e.g., C1q and MVIC (r = - 0.837), apelin and SBP (r = - 0.854), and andropin and OGTT (r = - 0.729)]. These results showed that greater decreases in plasma C1q and greater increases in apelin and adropin concentrations were associated with greater improvements in outcome measures after DSW than after ASW.

Indexed as

AgedAged, 80 and overApelinBlood PressureCholesterolComplement C1qFemaleGlucose Tolerance TestHumansInsulinIntercellular Signaling Peptides and ProteinsIsometric ContractionLipidsMiddle AgedObesityPhysical FitnessApelinCholesterolComplement C1qEnho protein, humanInsulinIntercellular Signaling Peptides and ProteinsLipids

Identifiers

PMID34480035
PMCPMC8417101
OpenAlexW3198747691

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.