Evidence map›Paper›PMID 34479984›Full record

ArticleLife science alliance2021

Biallelic

Danique Beijer, Thomas Agnew, Johannes Gregor Matthias Rack, Evgeniia Prokhorova, Tine Deconinck, Berten Ceulemans, Stojan Peric, Vedrana Milic Rasic, Peter De Jonghe, Ivan Ahel and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Spectrum of Hereditary Neuropathies in Adult Patients From Serbia.Journal of the peripheral nervous system : JPNS · 2026
    Article
  2. NovelNeurology. Genetics · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology.Frontiers in cell and developmental biology · 2022
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Danique BeijerTranslational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.ORCID 0000-0001-6593-7644
Thomas AgnewSir William Dunn School of Pathology, Oxford University, Oxford, UK.
Johannes Gregor Matthias RackSir William Dunn School of Pathology, Oxford University, Oxford, UK.ORCID 0000-0001-8341-6439
Evgeniia ProkhorovaSir William Dunn School of Pathology, Oxford University, Oxford, UK.ORCID 0000-0002-5467-5586
Tine DeconinckTranslational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Berten CeulemansDepartment of Pediatric Neurology, Antwerp University Hospital, Antwerp, Belgium.
Stojan PericNeurology Clinic, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Vedrana Milic RasicClinic for Neurology and Psychiatry for Children and Youth, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Peter De JongheTranslational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Ivan AhelSir William Dunn School of Pathology, Oxford University, Oxford, UK ivan.ahel@path.ox.ac.uk.ORCID 0000-0002-9446-3756
Jonathan BaetsTranslational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium Jonathan.Baets@uantwerpen.be.ORCID 0000-0001-8295-5385
University of Antwerp · BEUniversity of Oxford · GBUniversity of Belgrade · RSAntwerp University Hospital · BE

Funding

Biotechnology and Biological Sciences Research Council BB/R007195/1Cancer Research UK 22284Wellcome Trust 210634/Z/18/Z
6 · The paper itself

Abstract

ADP ribosylation is a reversible posttranslational modification mediated by poly(ADP-ribose)transferases (e.g., PARP1) and (ADP-ribosyl)hydrolases (e.g., ARH3 and PARG), ensuring synthesis and removal of mono-ADP-ribose or poly-ADP-ribose chains on protein substrates. Dysregulation of ADP ribosylation signaling has been associated with several neurodegenerative diseases, including Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. Recessive

Indexed as

AdolescentADP-RibosylationAdultAllelesDNA DamageDNA RepairFamilyFemaleGlycoside HydrolasesHumansMaleMutationNeuralgiaPedigreePoly Adenosine Diphosphate RibosePoly (ADP-Ribose) Polymerase-1ADPRS protein, humanGlycoside HydrolasesPARP1 protein, humanPoly Adenosine Diphosphate RibosePoly (ADP-Ribose) Polymerase-1

Identifiers

PMID34479984
PMCPMC8424258
OpenAlexW3197649960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.