Evidence map›Paper›PMID 34479942›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Murine Inducible Nitric Oxide Synthase Expression Is Essential for Antifungal Defenses in Kidneys during Disseminated

Kristie D Goughenour, Jessica Zhao, Jintao Xu, Ziyin P Zhao, Anutosh Ganguly, Christine M Freeman, Michal A Olszewski

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. A Cyclam Salt as an Antifungal Agent: Interference withAntibiotics (Basel, Switzerland) · 2024
    Article
  6. Editorial: Rising stars in fungal pathogenesis: 2023.Frontiers in cellular and infection microbiology · 2024
    Article
  7. Frontiers in cellular and infection microbiology · 2024
    Article
  8. Immunological Analysis of Cryptococcal Meningoencephalitis in a Murine Model.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kristie D GoughenourResearch Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System, Ann Arbor, MI.ORCID 0000-0003-2915-6765
Jessica ZhaoResearch Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System, Ann Arbor, MI.ORCID 0000-0003-1323-2030
Jintao XuResearch Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System, Ann Arbor, MI.
Ziyin P ZhaoDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI; and.ORCID 0000-0002-5457-059X
Anutosh GangulyDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI; and.
Christine M FreemanResearch Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System, Ann Arbor, MI.
Michal A OlszewskiResearch Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs Health System, Ann Arbor, MI; olszewsm@umich.edu.ORCID 0000-0001-7474-0843
VA Ann Arbor Healthcare System · USMichigan Medicine · USUniversity of Michigan · US

Funding

PULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9M
Modulation of Pulmonary Defenses in Pathobiology of Chronic InfectionsI01BX000656 · VA · VETERANS HEALTH ADMINISTRATION · PI OLSZEWSKI, MICHAL A · 2011 to 2025
–
Regulatory T Cell Inhibition of Natural Killer Cells in COPDI01CX001553 · VA · VETERANS HEALTH ADMINISTRATION · PI Christine M Basmajian · 2017 to 2026
–
BLR&D Research Career Scientist Award ApplicationIK6BX003615 · VA · VETERANS HEALTH ADMINISTRATION · PI OLSZEWSKI, MICHAL A · 2017 to 2021
–
BLRD VA I01 BX000656BLRD VA IK6 BX003615CSRD VA I01 CX001553NHLBI NIH HHS T32 HL007749
6 · The paper itself

Abstract

Disseminated cryptococcosis has a nearly 70% mortality, mostly attributed to CNS infection, with lesser-known effects on other organs. Immune protection against

Indexed as

CryptococcosisCryptococcusAnimalsAntifungal AgentsKidneyMiceMice, Inbred C57BLNitric Oxide Synthase Type IIAntifungal AgentsNitric Oxide Synthase Type II

Identifiers

PMID34479942
PMCPMC8492526
OpenAlexW3198719881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.