Evidence map›Paper›PMID 34479491›Full record

ArticleBMC infectious diseases2021

Study protocol of the PIMPI-project, a cohort study on acceptance, tolerability and immunogenicity of second trimester maternal pertussis immunization in relation to term and preterm infants.

Maarten M Immink, Mireille N Bekker, Hester E de Melker, Nynke Y Rots, Elisabeth A M Sanders, Nicoline A T van der Maas

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maarten M ImminkCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3720 MA, Bilthoven, The Netherlands. maarten.immink@rivm.nl.ORCID http://orcid.org/0000-0001-9266-379X
Mireille N BekkerDepartment of Obstetrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, and Utrecht University, Utrecht, The Netherlands.
Hester E de MelkerCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3720 MA, Bilthoven, The Netherlands.
Nynke Y RotsCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3720 MA, Bilthoven, The Netherlands.
Elisabeth A M SandersCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3720 MA, Bilthoven, The Netherlands.
Nicoline A T van der MaasCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3720 MA, Bilthoven, The Netherlands.
National Institute for Public Health and the Environment · NLUtrecht University · NL

Funding

ZonMw 522004008
6 · The paper itself

Abstract

backgroundMaternal immunization confers passive immunity to the fetus by transplacental antibody transfer. Infants may be better protected against pertussis if the mother received a diphtheriae, tetanus and acellular pertussis (Tdap) vaccination in the second trimester of pregnancy compared to the third trimester. This study evaluates IgG antibody concentrations in term and preterm infants at birth and 2 months after birth after maternal Tdap-vaccination between 20

methodsThis prospective cohort study consists of two parts. In the acceptance part, pregnant women complete a questionnaire on determinants that underlie acceptance of a second trimester Tdap-vaccination, which is offered subsequently between 20 DISCUSSION: This study investigates acceptance, tolerability and immunogenicity regarding maternal Tdap-immunization between 20

trial registrationEU Clinical Trials Register, 2018-002976-41, retrospectively registered 24 July 2019, https://www.clinicaltrialsregister.eu/ctr-search/search?query=2018-002976-41 .

Indexed as

Diphtheria-Tetanus-acellular Pertussis VaccinesWhooping CoughAntibodies, BacterialClinical Trials as TopicCohort StudiesFemaleHumansImmunizationInfantInfant, NewbornInfant, PrematurePregnancyPregnancy Trimester, SecondProspective StudiesVaccinationAntibodies, BacterialDiphtheria-Tetanus-acellular Pertussis VaccinesAcceptanceImmunogenicityMaternal immunizationPertussisPrematurityTolerabilityVaccination

Identifiers

PMID34479491
PMCPMC8414744
OpenAlexW3198397968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.