Evidence map›Paper›PMID 34479480›Full record

ArticleBMC gastroenterology2021

Tri-modal management of primary small cell carcinoma of the pancreas (SCCP): a rare neuroendocrine carcinoma (NEC).

Safa Elzein, Fei Bao, Ray Lin, Gabriel Schnickel, Andrew M Lowy, Gregory P Botta

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Safa ElzeinDepartment of Internal Medicine, Scripps Clinic/Green Hospital, 10666 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Fei BaoDepartment of Pathology, Scripps Clinic/Green Hospital, 10666 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Ray LinScripps Health Radiation Oncology, 10666 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Gabriel SchnickelDivision of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California San Diego, 3855 Health Sciences Road, La Jolla, CA, 92037, USA.
Andrew M LowyDivision of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California San Diego, 3855 Health Sciences Road, La Jolla, CA, 92037, USA.
Gregory P BottaDepartment of Medicine, Division of Hematology/Oncology, Moores Cancer Center, University of California San Diego, 3855 Health Sciences Road, La Jolla, CA, 92037, USA. gbotta@ucsd.edu.ORCID http://orcid.org/0000-0001-9606-4508
Scripps Green Hospital · USUniversity of California San Diego · USScripps Health · USUC San Diego Health System · US

Funding

Scripps Translational Science InstituteKL2TR001112 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2013 to 2017
$3.0M
NCATS NIH HHS KL2 TR001112NCATS NIH HHS KL2TR001112NCI NIH HHS LRP KYGF9753
6 · The paper itself

Abstract

backgroundPrimary small cell carcinoma of the pancreas (SCCP) is a rare malignant neuroendocrine carcinoma (NEC). Typically, it presents with lymphovascular invasion as well as metastasis at the time of diagnosis which portends a dismal prognosis. Treatment is typically based on therapy used for other aggressive NECs such as small cell lung cancer. Although multimodal surgery, radiation and chemotherapy may improve prognosis, the outcome generally remains poor. CASE PRESENTATION: Here we present a primary SCCP managed with neoadjuvant multi-agent chemotherapy combined with radiotherapy and surgery

conclusionsMulti-disciplinary therapy resulted in an ongoing 28 + month radiographic complete response and overall survival.

Indexed as

Carcinoma, NeuroendocrineCarcinoma, Small CellLung NeoplasmsPancreatic NeoplasmsSmall Cell Lung CarcinomaHumansInfant, NewbornPancreasPrognosisCarcinomaNeuroendocrine carcinomaPancreasSmall cell

Identifiers

PMID34479480
PMCPMC8414857
OpenAlexW3198762054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.