Evidence map›Paper›PMID 34479416›Full record

ArticleMicrobiology spectrum2021

Prognostic Performance of Peripheral Blood Biomarkers in Identifying Seropositive Individuals at Risk of Developing Clinically Symptomatic Chagas Cardiomyopathy.

Subhadip Choudhuri, Suresh K Bhavnani, Weibin Zhang, Valentina Botelli, Natalia Barrientos, Facundo Iñiguez, Maria Paola Zago, Nisha Jain Garg

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. An Update on Vaccines AgainstPathogens (Basel, Switzerland) · 2025
    Review
  5. Review
  6. RNA binding proteins in cardiovascular development and disease.Current topics in developmental biology · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Subhadip ChoudhuriDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Suresh K BhavnaniInstitute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA.
Weibin ZhangDepartment Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas, USA.
Valentina BotelliServicio de Cardiología, Hospital San Bernardo, Salta, Argentina.
Natalia BarrientosServicio de Cardiología, Hospital San Bernardo, Salta, Argentina.
Facundo IñiguezServicio de Cardiología, Hospital San Bernardo, Salta, Argentina.
Maria Paola ZagoInstituto de Patología Experimental, CONICET-Universidad Nacional de Salta (UNSa), Salta, Argentina.
Nisha Jain GargDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0002-3453-2369
The University of Texas Medical Branch at Galveston · USNational University of Salta · AR

Funding

UTMB Clinical and Translational Science AwardUL1TR001439 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI URBAN, RANDALL J · 2015 to 2024
$40.0M
UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
Oxidative Response Networks in Chagasic CardiomyopathyR01AI136031 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Nisha Jain Garg · 2017 to 2026
$3.6M
NCATS NIH HHS UL1 TR001439NIAID NIH HHS R01 AI136031NIA NIH HHS P30 AG024832
6 · The paper itself

Abstract

Biomarkers for prognosis-based detection of Trypanosoma cruzi-infected patients presenting no clinical symptoms to cardiac Chagas disease (CD) are not available. In this study, we examined the performance of seven biomarkers in prognosis and risk of symptomatic CD development. T. cruzi

Indexed as

BiomarkersChagas CardiomyopathyChagas DiseaseHumansLeukocytes, MononuclearPoly (ADP-Ribose) Polymerase-1PrognosisTrypanosoma cruziVentricular Function, LeftBiomarkersPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1biomarkers’ prognostic performanceChagas cardiomyopathyinfectious diseasepredictive risk analysisTrypanosoma cruzi

Identifiers

PMID34479416
PMCPMC8552597
OpenAlexW3196258374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.