Evidence map›Paper›PMID 34478882›Full record

ArticleClinical immunology (Orlando, Fla.)2021

Impact of the COVID-19 pandemic in patients with systemic lupus erythematosus throughout one year.

Giuseppe A Ramirez, Lorenza M Argolini, Chiara Bellocchi, Luca Moroni, Emanuel Della-Torre, Nicola Farina, Roberto F Caporali, Lorenzo Beretta, Maria Gerosa, Enrica P Bozzolo and 2 more

Open access · greenAbstract read
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Giuseppe A RamirezUniversità Vita-Salute San Raffaele, Milan, Italy; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy. Electronic address: ramirez.giuseppealvise@hsr.it.
Lorenza M ArgoliniUnit of Clinical Rheumatology, ASST Gaetano Pini -CTO, Milan, Italy.
Chiara BellocchiReferral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Policlinico, Milan, Italy; Università degli Studi di Milano, Milan, Italy.
Luca MoroniUniversità Vita-Salute San Raffaele, Milan, Italy; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
Emanuel Della-TorreUniversità Vita-Salute San Raffaele, Milan, Italy; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
Nicola FarinaUniversità Vita-Salute San Raffaele, Milan, Italy; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
Roberto F CaporaliUnit of Clinical Rheumatology, ASST Gaetano Pini -CTO, Milan, Italy; Department of Clinical Science of Community Health and Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milan, Italy.
Lorenzo BerettaReferral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Policlinico, Milan, Italy; Università degli Studi di Milano, Milan, Italy.
Maria GerosaUnit of Clinical Rheumatology, ASST Gaetano Pini -CTO, Milan, Italy; Department of Clinical Science of Community Health and Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milan, Italy.
Enrica P BozzoloUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
Lorenzo DagnaUniversità Vita-Salute San Raffaele, Milan, Italy; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
SMILE, Milan Lupus Consortium
Vita-Salute San Raffaele University · ITIstituto Ortopedico Gaetano Pini · ITUniversity of Milan · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIRCCS Ospedale San Raffaele · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Little is known about the impact of coronavirus disease 2019 (COVID-19) pandemic to the care of patients with systemic lupus erythematosus (SLE) in the long-term. By crossing population data with the results of a web-based survey focused on the timeframes January-April and May-December 2020, we found that among 334/518 responders, 28 had COVID-19 in 2020. Seventeen cases occurred in May-December, in parallel with trends in the general population and loosening of containment policy strength. Age > 40 years (p = 0.026), prednisone escalation (p = 0.008) and infected relatives (p < 0.001) were most significantly associated with COVID-19. Weaker associations were found with asthma, lymphadenopathy and azathioprine or cyclosporine treatment. Only 31% of patients with infected relatives developed COVID-19. Healthcare service disruptions were not associated with rising hospitalisations. Vaccination prospects were generally welcomed. Our data suggest that COVID-19 has a moderate impact on patients with SLE, which might be significantly modulated by public health policies, including vaccination.

Indexed as

SARS-CoV-2AdolescentAdultAgingCOVID-19COVID-19 VaccinesData CollectionFemaleHumansImmunosuppressive AgentsIncidenceLupus Erythematosus, SystemicMaleMiddle AgedSurveys and QuestionnairesVaccination RefusalCOVID-19 VaccinesImmunosuppressive AgentsContainmentCoronavirusCOVID-19LockdownPrednisonePublic healthSystemic lupus erythematosusTreatmentVaccination

Identifiers

PMID34478882
PMCPMC8405598
OpenAlexW3198139207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.