Evidence map›Paper›PMID 34478825›Full record

ArticleExperimental gerontology2021

Changes in body weight and metabolic risk during time restricted feeding in premenopausal versus postmenopausal women.

Sofia Cienfuegos, Kelsey Gabel, Faiza Kalam, Mark Ezpeleta, Shuhao Lin, Krista A Varady

Abstract read
In one paragraph

Article in Experimental gerontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sofia CienfuegosDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Kelsey GabelDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Faiza KalamDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Mark EzpeletaDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Shuhao LinDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Krista A VaradyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: varady@uic.edu.

Funding

Alternate day fasting combined with exercise for the treatment of NAFLDR01DK119783 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VARADY, KRISTA AMY · 2019 to 2022
$1.4M
NIDDK NIH HHS R01 DK119783
6 · The paper itself

Abstract

backgroundTime restricted feeding (TRF) involves confining the eating window to a specific number of hours, and fasting for the remaining hours of the day.

objectiveThis study examined if changes in body weight and metabolic risk factors during TRF, differ between premenopausal and postmenopausal women.

methodsThis is a secondary analysis of an 8-week TRF study (4-6 h eating window, 18-20 h fasting window daily) conducted in adults with obesity. Male participants were excluded, and female subjects were classified in two groups based on menstrual status: premenopausal (n = 13), or postmenopausal (n = 19). Perimenopausal women were excluded from the original study.

resultsBody weight decreased by week 8 in premenopausal women (-3.3 ± 0.4%) and postmenopausal women (-3.3 ± 0.5%) (main effect of time, P < 0.001), with no difference between groups (no group × time interaction). Adherence was excellent in both groups, with premenopausal women adhering to their prescribed eating window on 6.2 ± 0.1 d/week, and postmenopausal women adhering to their window on 6.2 ± 0.2 d/week. Fat mass, lean mass, fasting insulin, insulin resistance, and 8-isoprostane (marker of oxidative stress) were reduced similarly in both groups (main effect of time, P < 0.05 for all comparisons). Visceral fat mass, relative skeletal muscle index (RSMI), blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, HbA1c, TNF-alpha and IL-6 remained unchanged in both groups by week 8.

conclusionThese findings suggest that the weight loss and metabolic benefits of TRF do not differ between premenopausal and postmenopausal women with obesity.

Indexed as

FastingInsulin ResistanceBody Mass IndexBody WeightFemaleHumansMalePostmenopausePremenopauseIntermittent fastingMenopauseMetabolic diseaseObesityTime restricted feedingWomen

Identifiers

PMID34478825
PMCPMC8464526

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.