Evidence map›Paper›PMID 34478649›Full record

ArticleStem cell reports2021

The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development.

Ana Nacarino-Palma, Francisco J González-Rico, Claudia M Rejano-Gordillo, Ana Ordiales-Talavero, Jaime M Merino, Pedro M Fernández-Salguero

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Efficient Generation of Functional TCRαβbioRxiv : the preprint server for biology · 2026
    Article
  6. Review
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  11. Review
  12. Article
  13. Review
  14. Article
  15. Aryl Hydrocarbon Receptor: From Homeostasis to Tumor Progression.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ana Nacarino-PalmaDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s/n, 06071 Badajoz, Spain; Instituto de Investigación Biosanitaria de Extremadura (INUBE), Avenida de la Investigación s/n, 06071 Badajoz, Spain.
Francisco J González-RicoDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s/n, 06071 Badajoz, Spain; Instituto de Investigación Biosanitaria de Extremadura (INUBE), Avenida de la Investigación s/n, 06071 Badajoz, Spain.
Claudia M Rejano-GordilloDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s/n, 06071 Badajoz, Spain; Instituto de Investigación Biosanitaria de Extremadura (INUBE), Avenida de la Investigación s/n, 06071 Badajoz, Spain.
Ana Ordiales-TalaveroDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s/n, 06071 Badajoz, Spain; Instituto de Investigación Biosanitaria de Extremadura (INUBE), Avenida de la Investigación s/n, 06071 Badajoz, Spain.
Jaime M MerinoDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s/n, 06071 Badajoz, Spain; Instituto de Investigación Biosanitaria de Extremadura (INUBE), Avenida de la Investigación s/n, 06071 Badajoz, Spain. Electronic address: jmmerino@unex.es.
Pedro M Fernández-SalgueroDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s/n, 06071 Badajoz, Spain; Instituto de Investigación Biosanitaria de Extremadura (INUBE), Avenida de la Investigación s/n, 06071 Badajoz, Spain. Electronic address: pmfersal@unex.es.
Centro Tecnológico Agroalimentario de Extremadura · ESInstituto de Investigación Biosanitaria de Granada · ESUniversidad de Extremadura · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian embryogenesis is a complex process controlled by transcription factors that regulate the balance between pluripotency and differentiation. Transcription factor aryl hydrocarbon receptor (AhR) regulates OCT4/POU5F1 and NANOG, both essential controllers of pluripotency, stemness and early embryo development. Molecular mechanisms controlling OCT4/POU5F1 and NANOG during embryogenesis remain unidentified. We show that AhR regulates pluripotency factors and maintains the metabolic activity required for proper embryo differentiation. AhR-lacking embryos (AhR

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationEmbryo, MammalianEmbryonic DevelopmentEnergy MetabolismGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGenotypeGlycolysisHippo Signaling PathwayMiceOctamer Transcription Factor-3Oxidative StressProtein TransportReceptors, Aryl HydrocarbonAhr protein, mouseBasic Helix-Loop-Helix ProteinsOctamer Transcription Factor-3Pou5f1 protein, mouseReceptors, Aryl Hydrocarbonaryl hydrocarbon receptorembryo differentiationHippopluripotencypreimplantation

Identifiers

PMID34478649
PMCPMC8452532
OpenAlexW3197065607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.