Evidence map›Paper›PMID 34478640›Full record

ArticleCancer cell2021

Bacteria and fungi: The counteracting modulators of immune responses to radiation therapy in cancer.

Erick Riquelme, Florencia McAllister

Abstract readComment
In one paragraph

Article in Cancer cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Mycobiome: an underexplored kingdom in cancer.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  2. Review
  3. Article
  4. Fungi in cancer.Nature reviews. Cancer · 2024
    Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Erick RiquelmeCenter for Integrative Biology, Faculty of Science, Universidad Mayor, Santiago, Chile; FONDAP Geroscience Center for Brain Health and Metabolism, Santiago, Chile.
Florencia McAllisterDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: fmcallister@mdanderson.org.

Funding

Dissecting the Source and Mechanisms of IL-17-Mediated Modulation of Pancreatic TumorigenesisR37CA237384 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MCALLISTER, FLORENCIA · 2020 to 2025
$2.6M
NCI NIH HHS R37 CA237384
6 · The paper itself

Abstract

In this issue of Cancer Cell, Shiao et al. reveal the counteracting role of bacteria and fungi in antitumoral immune responses to radiation therapy (RT). While bacterial depletion impairs the response, fungal depletion improves efficacy of RT. An interplay between innate and adaptive immunity is implicated and orchestrated by Dectin-1.

Indexed as

Lectins, C-TypeNeoplasmsBacteriaFungiHumansImmunity, InnateLectins, C-Type

Identifiers

PMID34478640
PMCPMC11073472

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.