ArticlePloS one2021
Autonomic, endocrine, and psychological stress responses to different forms of blood draw.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Non-contact alcohol detection in mice using an imaging photoplethysmography (IPPG) system.Scientific reports · 2026Article
- Male Stress Is Associated with Ovarian and Endometrial Responses in ICSI Cycles: Is Seminal Plasma the Linchpin?International journal of molecular sciences · 2026Article
- Therapeutic potential and mechanisms of rehabilitation interventions in preventing cancer metastasis.Frontiers in oncology · 2026Review
- Feasibility of a brief group-based immersive 360° mindfulness program for stress-related outcomes in health sciences students: a 4-week pre-post pilot study.Frontiers in medicine · 2026Article
- Quantitative comparison of whole blood, plasma and serum metabolomes across different blood collection methods.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Menstrual Blood as a Non-Invasive Alternative for Monitoring Vitamin Levels.Journal of clinical medicine · 2024Article
- Exploring the Impact of Blood Draws on the Intraocular Pressure of Older Adults: A Focus on Physiological Responses.Journal of clinical medicine · 2024Article
- Stress Biomarkers Transferred Into the Female Reproductive Tract by Seminal Plasma Are Associated with ICSI Outcomes.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Concordance of hemoglobin A1c and reproductive hormone levels in menstrual and venous blood.F&S reports · 2024Article
- Fever glove hand-shake method safe blood collection from children's fingertips in COVID-19 fever clinic.World journal of clinical cases · 2023Article
- Predicting vasovagal reactions to needles with anticipatory facial temperature profiles.Scientific reports · 2023Article
- CCA identifies a neurophysiological marker of adaptation capacity that is reliably linked to internal locus of control of cognition in amnestic MCI.GeroScience · 2023Article
- Applying minimally invasive biomarkers of chronic stress across complex ecological contexts.American journal of human biology : the official journal of the Human Biology Council · 2022Review
- Lack of Evidence for a Relationship Between Salivary CRP and Women's Sexual Desire: An Investigation Across Clinical and Healthy Samples.The journal of sexual medicine · 2022Article
- Nociception related biomolecules in the adult human saliva: A scoping review with additional quantitative focus on cortisol.Molecular painArticle
- Physiological and hormonal stress response during blood donation in healthy voluntary donors.Asian journal of transfusion scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough fingerstick is often favorably compared to venipuncture as a less invasive method of drawing blood for clinical labs, there is little empirical research that compares physical and psychological stress responses to fingerstick vs. venipuncture (blood draw using a needle in the arm) within the same person. METHODS AND
findingsWe assessed changes in cortisol (a stress hormone), heart rate variability (a marker of autonomic stress), and psychological stress in 40 healthy women who completed both venipuncture and fingerstick. Contrary to our predictions, there was a significant decline in cortisol across conditions, with greater decline from pre- to post-draw in response to venipuncture than fingerstick. There were similar patterns of rise and fall in heart rate variability in both types of blood draw, suggestive of mild vasovagal responses. Psychological measures of stress (such as negative emotion and perceived stress) were generally stronger predictors of participant's reported pain and blood draw preferences than physical stress measures.
conclusionsThese findings challenge the characterization of fingerstick as necessarily "less invasive" than venipuncture, as participant's stress responses to fingerstick were equivalent to (and for some measures greater than) their response to venipuncture. Heart rate variability response to fingerstick significantly predicted that individual's vasovagal-like responses to venipuncture, suggesting that measuring heart rate variability during pre-donation hemoglobin testing may identify donors at risk for adverse events during venipuncture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.