Evidence map›Paper›PMID 34478259›Full record

ArticleACS infectious diseases2021

Total Synthesis of Tetrahydrolipstatin, Its Derivatives, and Evaluation of Their Ability to Potentiate Multiple Antibiotic Classes against

Saniya S Khan, Thanuja D Sudasinghe, Alexander D Landgraf, Donald R Ronning, Steven J Sucheck

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Saniya S KhanDepartment of Chemistry & Biochemistry, University of Toledo, Toledo, Ohio 43606, United States.
Thanuja D SudasingheDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Alexander D LandgrafDepartment of Chemistry & Biochemistry, University of Toledo, Toledo, Ohio 43606, United States.
Donald R RonningDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID 0000-0003-2583-8849
Steven J SucheckDepartment of Chemistry & Biochemistry, University of Toledo, Toledo, Ohio 43606, United States.ORCID 0000-0003-0082-3827
University of Toledo · USUniversity of Nebraska Medical Center · US

Funding

Understanding trehalose synthesis and utilization in mycobacteriaR01AI105084 · NIAID · UNIVERSITY OF TOLEDO · PI RONNING, DONALD R, SUCHECK, STEVEN · 2013 to 2022
$3.7M
NIAID NIH HHS R01 AI105084
6 · The paper itself

Abstract

Tetrahydrolipstatin (THL,

Indexed as

Mycobacterium tuberculosisAnimalsAntitubercular AgentsIsoniazidMicrobial Sensitivity TestsOrlistatAntitubercular AgentsIsoniazidOrlistatactivity-based protein profiling (ABPP)Ag85C inhibitiondrug synergyMICMycobacterium tuberculosis (Mtb)tetrahydrolipstatin

Identifiers

PMID34478259
PMCPMC8630808
OpenAlexW3198642572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.