ArticleCancer2022
Social determinants of health and cancer mortality in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study.
Article in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
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Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The correlation between social support and hopelessness among cancer survivors: a meta-analysis.Cancer causes & control : CCC · 2026Pooled it
- Race and Ethnicity Disparities in Cardiovascular and Cancer Mortality: the Role of Socioeconomic Status-a Systematic Review and Meta-analysis.Journal of racial and ethnic health disparities · 2025Pooled it
- A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality.Nature human behaviour · 2023Pooled it
- Addressing Economic Insecurities Can Improve Patient-Reported Outcomes in Lupus.Arthritis care & research · 2026Article
- Residential Context and Survival Disparities in Black and White Women With Ovarian Cancer.JAMA network open · 2026Observational
- Overcoming social determinants: World trade center health program monitoring use among the general responders.Preventive medicine reports · 2026Article
- Self-advocacy training within a peer navigation model in advanced cancer: a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- The LIFT UP study: feasibility of systematically identifying and addressing resource needs in those with metastatic breast cancer.Breast cancer research and treatment · 2026Article
- Characterizing Social Determinants of Health in GI Cancer Surgery: Insights From the All of Us Research Program.Cancer reports (Hoboken, N.J.) · 2026Article
- Racial and Ethnic Disparities in Second Primary Lung Cancer After Breast Radiotherapy: A SEER Cohort Analysis (2000-2022).Cancers · 2026Article
- Understanding Cancer Health Disparities.Cancers · 2026Review
- Practical Considerations for using Social Determinants of Health for Disease Prediction in All of Us.Research square · 2026Article
- Social Determinants of Health Associated with Multiple Myeloma Incidence and Survival among a Low-Income Cohort in the Southeastern U.S.medRxiv : the preprint server for health sciences · 2026Article
- Influence of Pre-treatment CA 125 Levels on Survival Outcomes Across Ethnic Groups in Ovarian Cancer Patients.Journal of community hospital internal medicine perspectives · 2026Article
- Reasons for referral to a social prescribing program through the COVID-19 pandemic and associated factors: a cross-sectional study in Portugal.Frontiers in public health · 2026Article
- Social genomics and cancer - untangling nature from nurture in squamous cell carcinoma outcomes.Frontiers in oncology · 2026Review
- Practical considerations for social determinant-based disease prediction in the All of Us research program.Communications health · 2026Article
- Association between County Health Rankings Factors and County-level Genitourinary Cancer Mortality.Journal of racial and ethnic health disparities · 2025Article
- Loneliness and Risk of 30-Day Hospital Readmission After Acute Myocardial Infarction.Medical care · 2025Article
- Assessing Social Determinants of Health in Transplantation and CAR-T Recipients: Expert Panel Recommendations from the Survivorship Special Interest Group of ASTCT.Transplantation and cellular therapy · 2025Review
18 more citing papers are in PubMed but not listed here.
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Abstract
backgroundSocial determinants of health (SDOHs) cluster together and can have deleterious impacts on health outcomes. Individually, SDOHs increase the risk of cancer mortality, but their cumulative burden is not well understood. The authors sought to determine the combined effect of SDOH on cancer mortality.
methodsUsing the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, the authors studied 29,766 participants aged 45+ years and followed them 10+ years. Eight potential SDOHs were considered, and retained SDOHs that were associated with cancer mortality (P < .10) were retained to create a count (0, 1, 2, 3+). Cox proportional hazard models estimated associations between the SDOH count and cancer mortality through December 31, 2017, adjusting for confounders. Models were age-stratified (45-64 vs 65+ years).
resultsParticipants were followed for a median of 10.6 years (interquartile range [IQR], 6.5, 12.7 years). Low education, low income, zip code poverty, poor public health infrastructure, lack of health insurance, and social isolation were significantly associated with cancer mortality. In adjusted models, among those <65 years, compared to no SDOHs, having 1 SDOH (adjusted hazard ratio [aHR], 1.39; 95% CI, 1.11-1.75), 2 SDOHs (aHR, 1.61; 95% CI, 1.26-2.07), and 3+ SDOHs (aHR, 2.09; 95% CI, 1.58-2.75) were associated with cancer mortality (P for trend <.0001). Among individuals 65+ years, compared to no SDOH, having 1 SDOH (aHR, 1.16; 95% CI, 1.00-1.35) and 3+ SDOHs (aHR, 1.26; 95% CI, 1.04-1.52) was associated with cancer mortality (P for trend = .032).
conclusionsA greater number of SDOHs were significantly associated with an increased risk of cancer mortality, which persisted after adjustment for confounders.
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