ArticleBrain imaging and behavior2022
Disrupted functional connectivity in white matter resting-state networks in unilateral temporal lobe epilepsy.
Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Dynamic Analysis of Gray Matter and White Matter Functional Network Connectivity in Individuals with Temporal Lobe Epilepsy.Research square · 2026Article
- Observational
- Disparities in Connectivity Profiles Between Structural and Functional Networks in Patients With Temporal Lobe Epilepsy.Brain and behavior · 2025Article
- The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy.Neuroscience bulletin · 2025Review
- WhiFuN: A toolbox to map the white matter functional networks of the human brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Aberrant white matter and subcortical gray matter functional network connectivity associated with static and dynamic characteristics in subjects with temporal lobe epilepsy.Frontiers in neuroscience · 2025Article
- Alteration in early resting‑state functional MRI activity in comatose survivors of cardiac arrest: a prospective cohort study.Critical care (London, England) · 2024Observational
- Neuroimaging epicenters as potential sites of onset of the neuroanatomical pathology in schizophrenia.Science advances · 2024Article
- Impaired interhemispheric synchrony and effective connectivity in right temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Brain activation and connection across resting and motor-task states in patients with generalized tonic-clonic seizures.CNS neuroscience & therapeutics · 2024Article
- Impaired orienting function detected through eye movements in patients with temporal lobe epilepsy.Frontiers in neuroscience · 2023Article
- Increased functional connectivity of white-matter in myotonic dystrophy type 1.Frontiers in neuroscience · 2022Article
- Temporal Lobe Spikes Affect Distant Intrinsic Connectivity Networks.Frontiers in neurology · 2021Article
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Authors and funding
14 authors at 3 institutions in 1 country.
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Abstract
Unilateral temporal lobe epilepsy (TLE) is the most common type of focal epilepsy characterized by foci in the unilateral temporal lobe grey matters of regions such as the hippocampus. However, it remains unclear how the functional features of white matter are altered in TLE. In the current study, resting-state functional magnetic resonance imaging (fMRI) was performed on 71 left TLE (LTLE) patients, 79 right TLE (RTLE) patients and 47 healthy controls (HC). Clustering analysis was used to identify fourteen white matter networks (WMN). The functional connectivity (FC) was calculated among WMNs and between WMNs and grey matter. Furthermore, the FC laterality of hemispheric WMNs was assessed. First, both patient groups showed decreased FCs among WMNs. Specifically, cerebellar white matter illustrated decreased FCs with the cerebral superficial WMNs, implying a dysfunctional interaction between the cerebellum and the cerebral cortex in TLE. Second, the FCs between WMNs and the ipsilateral hippocampus (grey matter foci) were also reduced in patient groups, which may suggest insufficient functional integration in unilateral TLE. Interestingly, RTLE showed more severe abnormalities of white matter FCs, including links to the bilateral hippocampi and temporal white matter, than LTLE. Taken together, these findings provide functional evidence of white matter abnormalities, extending the understanding of the pathological mechanism of white matter impairments in unilateral TLE.
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