Evidence map›Paper›PMID 34478015›Full record

ArticleAIDS and behavior2022

The Effect of PrEP Use Disclosure on Adherence in a Cohort of Adolescent Girls and Young Women in South Africa.

Danielle Giovenco, Audrey Pettifor, Kimberly A Powers, Lisa Hightow-Weidman, Brian W Pence, Jessie K Edwards, Katherine Gill, Jennifer F Morton, Ariane van der Straten, Connie Celum and 1 more

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Danielle GiovencoDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dgiovenco@unc.edu.ORCID http://orcid.org/0000-0002-2137-5309
Audrey PettiforDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kimberly A PowersDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lisa Hightow-WeidmanDepartment of Health Behavior and Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Brian W PenceDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jessie K EdwardsDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Katherine GillThe Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Jennifer F MortonDepartment of Global Health, University of Washington, Seattle, WA, USA.
Ariane van der StratenRTI International, Women's Global Health Imperative, Berkeley, CA, USA.
Connie CelumDepartment of Global Health, University of Washington, Seattle, WA, USA.
Linda-Gail BekkerThe Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
University of North Carolina at Chapel Hill · USDesmond Tutu HIV Foundation · ZAUniversity of Washington · USRTI International · US

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
Design and delivery of combination HIV prevention in young South African womenR01MH107251 · NIMH · DESMOND TUTU HIV FOUNDATION · PI BEKKER, LINDA-GAIL GAIL, CELUM, CONNIE L · 2015 to 2018
$2.0M
Social and psychological predictors of PrEP adherence among adolescent girls and young women in Eastern and Southern AfricaF31MH119965 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GIOVENCO, DANIELLE · 2019 to 2020
$75k
NIMH NIH HHS F31 MH119965NIMH NIH HHS F31MH119965NIMH NIH HHS P30 MH062246NIMH NIH HHS R01 MH107251NIMH NIH HHS R01MH107251
6 · The paper itself

Abstract

Effective strategies to support PrEP adherence among adolescent girls and young women (AGYW) are needed. We examined PrEP use disclosure and its effect on adherence among 200 AGYW ages 16-25 initiating PrEP in South Africa to help inform these  strategies. We estimated the relative prevalence of high adherence (intracellular tenofovir-diphosphate concentration ≥ 700 fmol/punch) 3- and 6-months after PrEP initiation among those who disclosed vs. did not disclose their PrEP use, both overall and by age. Most AGYW disclosed to a parent (58%), partner (58%), or friend (81%) by month 6. We did not observe a strong effect of disclosure on adherence overall; however, among younger AGYW (≤ 18 years), those who disclosed to a parent were 6.8 times as likely to have high adherence at month 6 than those who did not (95% CI 1.02, 45.56). More work is needed to understand parents' roles as allies and identify ways peers and partners can motivate PrEP use for AGYW.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisAdolescentAdultDisclosureFemaleHumansSouth AfricaYoung AdultAnti-HIV AgentsAdolescent girls and young womenDisclosureHIV preventionPre-exposure prophylaxisPrEP

Identifiers

PMID34478015
PMCPMC8891396
OpenAlexW3196312605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.