Evidence map›Paper›PMID 34478005›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2022

Characteristics of patients with esophageal motility disorders on high-resolution manometry and esophagography-a large database analysis in Japan.

Chiaki Sato, Hiroki Sato, Takashi Kamei, Yuto Shimamura, Shinwa Tanaka, Hironari Shiwaku, Junya Shiota, Ryo Ogawa, Hiroshi Yokomichi, Haruhiro Inoue

Abstract read
PubMed Publisher
In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Chiaki SatoDepartment of Surgery, Tohoku University School of Medicine, 1-1, Seiryomachi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. schiaki@surg.med.tohoku.ac.jp.ORCID 0000-0003-1449-2053
Hiroki SatoDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Takashi KameiDepartment of Surgery, Tohoku University School of Medicine, 1-1, Seiryomachi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
Yuto ShimamuraDigestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Shinwa TanakaDepartment of Gastroenterology, Kobe University Hospital, Kobe, Japan.
Hironari ShiwakuDepartment of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Junya ShiotaDepartment of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan.
Ryo OgawaDepartment of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan.
Hiroshi YokomichiDepartment of Health Sciences, University of Yamanashi, Yamanashi, Japan.
Haruhiro InoueDigestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Showa University · JPTohoku University · JPFukuoka University · JPKobe University Hospital · JPNagasaki University Hospital · JPNiigata University · JPOita University · JPUniversity of Yamanashi · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith the development of high-resolution manometry (HRM) and peroral endoscopy, more patients with esophageal motility disorders (EMDs) including achalasia are diagnosed and treated. The characteristics of Japanese patients with EMDs are unknown and should be elucidated.

methodsA large-scale database analysis was performed at seven high-volume centers in Japan. EMDs between 2010 and 2019 were analyzed.

resultsA total of 1900 patients were diagnosed with treatment naïve achalasia on esophagography. A long disease history was related to the sigmoid and dilated esophagus, and patients' symptom severity declined as achalasia progressed to the sigmoid type. Among 1700 patients received starlet HRM, 1476 (86.8%) completed the examination. Long disease history and sigmoid achalasia were identified as risk factors for the failure of HRM examination. Type I achalasia was the most common type found on starlet HRM, and 45.1% of patients with achalasia had lower esophageal sphincter (LES) pressure within the normal range. Type III had a high age of onset and mild symptom severity, compared to the other two subtypes. Type III achalasia, esophagogastric outflow obstruction (EGJ-OO), jackhammer esophagus (JE), and diffuse esophageal spasm (DES) were relatively rare compared to type I-II achalasia. The clinical characteristics of EGJ-OO, JE, and DES were generally close to those of achalasia.

conclusionThis first large-scale database analysis indicates that more Japanese patients with achalasia are type I and have a normal range of LES pressure on starlet HRM. Failure of HRM is not rare; therefore, esophagography continuously has a complementary role in achalasia diagnosis.

Indexed as

Esophageal AchalasiaEsophageal Motility DisordersHumansJapanManometryAchalasiaDiffuse esophageal spasmHigh-resolution manometryJackhammer esophagusOutflow obstruction

Identifiers

PMID34478005
OpenAlexW3197942193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.