ArticlePsychopharmacology2022
Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder.
Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Biomarker use in predicting transcranial direct-current stimulation (tDCS) response: a systematic scoping review.Frontiers in psychiatry · 2026Pooled it
- Predicting the treatment outcomes of major depressive disorder interventions with baseline resting-state functional connectivity: a meta-analysis.BMC psychiatry · 2025Pooled it
- Brain connectivity in major depressive disorder: a precision component of treatment modalities?Translational psychiatry · 2023Pooled it
- Effects of acute ebselen add-on treatment on resting state function connectivity in depressed patients with inadequate response to antidepressants.Scientific reports · 2026Trial
- Towards causal inference-based antidepressant selection with brain and blood biomarkers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Functional Connectivity Predicting Transdiagnostic Treatment Outcomes in Internalizing Psychopathologies.JAMA network open · 2025Trial
- A common symptom geometry of mood improvement under sertraline and placebo associated with distinct neural patterns.Psychological medicine · 2025Trial
- Resting-state functional connectivity of the default mode network as a predictor for escitalopram response in adolescents with depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Altered Dynamic Functional Connectivity of the Frontoparietal Network in Major Depressive Disorder: Evidence From a Large-Scale Resting-State fMRI Study.Brain and behavior · 2026Article
- Psilocybin effects on brain functional connectivity: a systematic review of fMRI studies.Discover mental health · 2026Review
- Treatment response to bupropion: an investigation of changes in resting-state functional connectivity in patients with major depressive disorder.Psychopharmacology · 2025Article
- Predicting antidepressant responsiveness in major depressive disorder patients via electroencephalography gamma-band dynamic functional connectivity in response to salient auditory stimuli.The international journal of neuropsychopharmacology · 2025Article
- Effects of canine-assisted intervention on stress and depression in humans.Journal of animal science and technology · 2025Review
- Association between the functional brain network and antidepressant responsiveness in patients with major depressive disorders: a resting-state EEG study.Psychological medicine · 2025Article
- Breakthroughs and challenges for generating brain network-based biomarkers of treatment response in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Early differences in lassitude predicts outcomes in Stanford Neuromodulation Therapy for difficult to treat depression.Npj mental health research · 2024Article
- Prediction of Early Antidepressant Efficacy in Patients with Major Depressive Disorder Based on Multidimensional Features of rs-fMRI andCanadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Article
- Study protocol for identifying resting brain functional connectivity markers of response to continuous Theta Burst Stimulation and cathodal transcranial Direct Current Stimulation in patients with schizophrenia with persistent auditory hallucinations.Wellcome open research · 2024Article
- Association of executive function with suicidality based on resting-state functional connectivity in young adults with subthreshold depression.Scientific reports · 2023Article
- Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine.Translational psychiatry · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
rationalWith no available response biomarkers, matching an appropriate antidepressant to an individual can be a lengthy process. Improving understanding of processes underlying treatment responsivity in depression is crucial for facilitating work on response biomarkers.
objectivesTo identify differences in patterns of pre-treatment resting-state functional connectivity (rsFC) that may underlie response to antidepressant treatment.
methodsAfter a baseline MRI scan, thirty-four drug-free patients with depression were treated with an SSRI escitalopram 10 mg daily for 6 weeks; response was defined as ≥ 50% decrease in Hamilton Depression Rating Scale (HAMD) score. Thirty-one healthy controls had a baseline clinical assessment and scan. Healthy participants did not receive treatment.
resultsTwenty-one (62%) of patients responded to escitalopram. Treatment responsivity was associated with enhanced rsFC of the right fronto-parietal network (FPN)-with the posterior DMN, somatomotor network (SMN) and somatosensory association cortex. The lack of treatment response was characterized by reduced rsFC: of the bilateral FPN with the contralateral SMN, of the right FPN with the posterior DMN, and of the extended sensorimotor auditory area with the inferior parietal lobule (IPL) and posterior DMN. Reduced rsFC of the posterior DMN with IPL was seen in treatment responders, although only when compared with HC.
conclusionsThe study supports the role of resting-state networks in response to antidepressant treatment, and in particular the central role of the frontoparietal and default mode networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.