Evidence map›Paper›PMID 34477552›Full record

ArticleeLife2021

LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells.

Bo-Ruei Chen, Yinan Wang, Anthony Tubbs, Dali Zong, Faith C Fowler, Nicholas Zolnerowich, Wei Wu, Amelia Bennett, Chun-Chin Chen, Wendy Feng and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. THE GID COMPLEX REGULATES DNA END PROCESSING DURING DNA DOUBLE-STRAND BREAK REPAIR BY NONHOMOLOGOUS END JOINING.Transactions of the American Clinical and Climatological Association · 2025
    Article
  5. Emerging Role of the DREAM Complex in Cancer and Therapeutic Opportunities.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. AGO2 silences mobile transposons in the nucleus of quiescent cells.Nature structural & molecular biology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Bo-Ruei ChenDivision of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, United States.ORCID 0000-0001-6404-2099
Yinan WangDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States.
Anthony TubbsLaboratory of Genome Integrity, National Cancer Institute, Bethesda, United States.
Dali ZongLaboratory of Genome Integrity, National Cancer Institute, Bethesda, United States.
Faith C FowlerDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States.
Nicholas ZolnerowichLaboratory of Genome Integrity, National Cancer Institute, Bethesda, United States.
Wei WuLaboratory of Genome Integrity, National Cancer Institute, Bethesda, United States.
Amelia BennettDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States.
Chun-Chin ChenDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States.
Wendy FengDivision of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, United States.ORCID 0000-0002-9734-8809
Andre NussenzweigLaboratory of Genome Integrity, National Cancer Institute, Bethesda, United States.
Jessica K TylerDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States.ORCID 0000-0001-9765-1659
Barry P SleckmanDivision of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, United States.ORCID 0000-0001-8295-4462
Cornell University · USNational Cancer Institute · USUniversity of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
THE V(D)J RECOMBINATION REACTION AND ITS IMPACT ON LYMPHOCYTE DEVELOPMENTR01AI047829 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SLECKMAN, BARRY P · 2000 to 2021
$7.0M
ATM FUNCTION DURING V(D)J RECOMBINATIONR01AI074953 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SLECKMAN, BARRY P · 2009 to 2023
$5.9M
Chromatin's Role in Repair of Radiation-induced Damage.R01CA095641 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2002 to 2023
$5.2M
Chromatin Assembly, Structure and FunctionR01GM064475 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2002 to 2019
$4.4M
Novel pathways that regulate DNA double-strand break repair events in mammalian cellsR35GM139816 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2021 to 2025
$2.1M
NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA095641NIAID NIH HHS R01 AI047829NIAID NIH HHS R01 AI074953NIGMS NIH HHS R01 GM064475NIGMS NIH HHS R35 GM139816
6 · The paper itself

Abstract

DNA double-strand break (DSB) repair by homologous recombination (HR) is thought to be restricted to the S- and G

Indexed as

DNA Breaks, Double-StrandedDNA End-Joining RepairBRCA1 ProteinDNA Repair EnzymesDNA ReplicationG1 PhaseG2 PhaseHomologous RecombinationHumansRad51 RecombinaseS PhaseTrans-ActivatorsTumor Suppressor p53-Binding Protein 1BRCA1 ProteinBRCA1 protein, humanDNA Repair EnzymesLIN37 protein, humanRAD51 protein, humanRad51 RecombinaseTP53BP1 protein, humanTrans-ActivatorsTumor Suppressor p53-Binding Protein 1cell biologychromosomesDSB repairgene expressionHRhumanLIN37mouseNHEJquiescenceresection

Identifiers

PMID34477552
PMCPMC8416021
OpenAlexW3198218416

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.