Evidence map›Paper›PMID 34477381›Full record

ArticleJournal of medicinal chemistry2021

Haloperidol Metabolite II Valproate Ester (

Carla Barbaraci, Giovanni Giurdanella, Claudia Giovanna Leotta, Anna Longo, Emanuele Amata, Maria Dichiara, Lorella Pasquinucci, Rita Turnaturi, Orazio Prezzavento, Ivana Cacciatore and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. HDAC/σ1R Dual-Ligand as a Targeted Melanoma Therapeutic.Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Carla BarbaraciDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-6155-6702
Giovanni GiurdanellaDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 97, 95123 Catania, Italy.
Claudia Giovanna LeottaVera Salus Ricerca S.r.l., Via Sigmund Freud 62/B, 96100 Siracusa, Italy.
Anna LongoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 97, 95123 Catania, Italy.
Emanuele AmataDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-4750-3479
Maria DichiaraDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Lorella PasquinucciDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0003-1309-3368
Rita TurnaturiDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-5895-7820
Orazio PrezzaventoDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-3521-264X
Ivana CacciatoreDepartment of Pharmacy, "G. D'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, Italy.ORCID 0000-0001-6253-0443
Elisa ZuccarelloTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York 10032, United States.
Gabriella LupoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 97, 95123 Catania, Italy.
Giovanni Mario PitariVera Salus Ricerca S.r.l., Via Sigmund Freud 62/B, 96100 Siracusa, Italy.ORCID 0000-0003-0698-8112
Carmelina Daniela AnfusoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 97, 95123 Catania, Italy.
Agostino MarrazzoDepartment of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-8728-8857
University of Catania · ITColumbia University · USUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to higher metastasis and mortality in uveal melanoma (UM), an aggressive malignancy of the eye in adults.

Indexed as

Angiogenesis InhibitorsButyrophenonesCell Line, TumorCell ProliferationCell SurvivalHumansMelanomaPentanoic AcidsPiperidinesProdrugsStereoisomerismUveal MelanomaUveal NeoplasmsValeratesAngiogenesis InhibitorsButyrophenonesMRJF22Pentanoic AcidsPiperidinesProdrugsValerates

Identifiers

PMID34477381
PMCPMC8474110
OpenAlexW3198161868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.