SynthesisThoracic cancer2021
Autologous blood pleurodesis for the treatment of postoperative air leaks. A systematic review and meta-analysis.
Synthesis in Thoracic cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Autologous blood pleurodesis for the treatment of postoperative air leaks. A systematic review and meta-analysis.Thoracic cancer · 2021Pooled it
- Trial
- Systematic or On-Demand Sealant Use in Minimally Invasive Lung Surgery: A Matched Comparison.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Multi-agent pleurodesis: a new horizon in management.AME case reports · 2026Article
- Autologous Blood Versus Talc Pleurodesis and the Influence of Non-steroidal Anti-inflammatory Drugs.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Polyglactin mesh in preventing recurrent pneumothorax in primary spontaneous pneumothorax: a retrospective efficacy study.Annals of translational medicine · 2025Article
- A Practical Approach to Pneumothorax Management.Pulmonary therapy · 2025Article
- Autologous Blood Pleurodesis Through an Indwelling Pleural Catheter for the Management of Prolonged Air Leak in a Malignant Hydropneumothorax.Respirology case reports · 2025Article
- Advancements in the Management of Postoperative Air Leak following Thoracic Surgery: From Traditional Practices to Innovative Therapies.Medicina (Kaunas, Lithuania) · 2024Review
- Predictors of reoperation after lung volume reduction surgery.Surgical endoscopy · 2024Article
- Effectiveness of pleurodesis for postoperative air leaks after lung resection.Journal of cardiothoracic surgery · 2024Article
- Prolonged air leak after robotic lung resection: a narrative review.Journal of thoracic disease · 2023Review
- Early Pleurodesis for Postoperative Air Leak with Autologous Blood and 50% Glucose Solution.Journal of chest surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative air leaks are a common complication after lung surgery. They are associated with prolonged hospital stay, increased postoperative pain and treatment costs. The treatment of prolonged air leaks remains controversial. Several treatments have been proposed including different types of sealants, chemical pleurodesis, or early surgical intervention. The aim of this review was to analyze the impact of autologous blood pleurodesis in a systematic way.
methodsA systematic review of the literature was conducted until July 2020. Studies with more than five adult patients undergoing lung resections were included. Studies in patients receiving blood pleurodesis for pneumothorax were excluded. The search strategy included proper combinations of the MeSH terms "air leak", "blood transfusion" and "lung surgery".
resultsTen studies with a total of 198 patients were included in the analysis. The pooled success rate for sealing the air leak within 48 h of the blood pleurodesis was 83.7% (95% CI: 75.7; 90.3). The pooled incidence of the post-interventional empyema was 1.5%, with a pooled incidence of post-interventional fever of 8.6%.
conclusionsCurrent evidence supports the idea that autologous blood pleurodesis leads to a faster healing of postoperative air leaks than conservative treatment. The complication rate is very low. Formal recommendations on how to perform the procedure are not possible with the current evidence. A randomized controlled trial in the modern era is necessary to confirm the benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.