Evidence map›Paper›PMID 34476886›Full record

ArticleHIV medicine2022

Decrease of condom use in heterosexual couples and its impact on pregnancy rates: the Swiss HIV Cohort Study (SHCS).

Anna Hachfeld, Andrew Atkinson, Alexandra Calmy, Begoña Martinez de Tejada, Barbara Hasse, Paolo Paioni, Christian R Kahlert, Noémie Boillat-Blanco, Marcel Stoeckle, Karoline Aebi-Popp and 1 more

Open access · hybridAbstract read
In one paragraph

Article in HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Anna Hachfeld *Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland.ORCID 0000-0001-9308-7130
Andrew Atkinson *Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland.
Alexandra CalmyDepartment of Infectious Diseases, Geneva University Hospitals, HIV/AIDS Unit, Geneva, Switzerland.
Begoña Martinez de TejadaObstetrics Division, Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Barbara HasseDivision of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Zurich, Switzerland.
Paolo PaioniDivision of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich, Zurich, Switzerland.
Christian R KahlertChildren's Hospital of Eastern Switzerland and Cantonal Hospital, St. Gallen, Switzerland.
Noémie Boillat-BlancoService of Infectious Diseases, University Hospital Lausanne, Lausanne, Switzerland.
Marcel StoeckleDepartment of Infectious Diseases, University Hospital Basel, Basel, Switzerland.
Karoline Aebi-PoppDepartment of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland.ORCID 0000-0002-9337-900X
Swiss HIV Cohort Study, the Swiss Mother, Child HIV Cohort Study (MoCHiV)
University of Bern · CHUniversity Hospital of Geneva · CHOstschweizer Kinderspital · CHSwiss HIV Cohort Study · CHUniversity Children's Hospital Zurich · CHUniversity Hospital of Basel · CHUniversity of Lausanne · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFollowing the 'Swiss statement' in 2008 it became an option to omit the use of condoms in serodiscordant couples and to conceive naturally. We analysed its impact on condom use and pregnancy events.

methodsIn all, 3023 women (aged 18-49 years) participating in the Swiss HIV Cohort Study were included. Observation time was divided into pre- and post-Swiss statement phases (July 2005-December 2008 and January 2009-December 2019). We used descriptive statistics, Poisson interrupted time series analysis for pregnancy incidence, and logistic regression to identify predictors of live births, spontaneous and induced abortions.

resultsCondomless sex in sexually active women increased from 25% in 2005 to 75% in 2019, while pregnancy incidence did not. Women after 2008 experienced higher spontaneous abortion rates (12.1% vs. 17.2%, p = 0.02) while induced abortion and live birth rates did not change significantly. Spontaneous abortions were more common in older women [adjusted odds ratio (aOR) = 1.4, 95% CI: 1.2-1.7, p < 0.001], in women consuming alcohol (aOR = 2.8, 95% CI: 1.9-4.1, p < 0.001) and in those with non-suppressed viral load (aOR = 0.2, 95% CI: 0.1-0.4, p ≤ 0.001). Induced abortions were more likely in women with depression (aOR = 3.4, 95% CI: 1.8-6.3, p < 0.001) and non-suppressed viral load (aOR = 0.3, 95% CI: 0.2-0.7, p = 0.003).

conclusionsThe publication of the Swiss statement resulted in more condomless sex in heterosexual women, but this did not result in a higher incidence of pregnancy. Maternal age and spontaneous abortion rates increased over time, while induced abortion rates were not significantly affected. Women living with HIV in Switzerland have an unmet need regarding family planning counselling.

Indexed as

CondomsHIV InfectionsAdolescentAdultAgedCohort StudiesFemaleHeterosexualityHumansMiddle AgedPregnancyPregnancy RateSwitzerlandYoung Adultabortioncondomfamily planningHIVpregnancy

Identifiers

PMID34476886
PMCPMC9290944
OpenAlexW3197162098

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.