Evidence map›Paper›PMID 34476841›Full record

ArticleAnnals of neurology2021

Sleep Deprivation Exacerbates Seizures and Diminishes GABAergic Tonic Inhibition.

Sai Surthi Konduru, Yu-Zhen Pan, Eli Wallace, Jesse A Pfammatter, Mathew V Jones, Rama K Maganti

Open access · greenAbstract read
In one paragraph

Article in Annals of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Seizure Susceptibility inmicroPublication biology · 2025
    Article
  9. Article
  10. Article
  11. [Screen exposure status and related factors in children with epilepsy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  12. Review
  13. Article
  14. Sleep deprivation drives brain-wide changes in cholinergic presynapse abundance inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Review
  16. Article
  17. To Not Sleep, Perchance to Seize.Epilepsy currents · 2022
    Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sai Surthi Konduru *Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Yu-Zhen Pan *Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Eli WallaceDepartment of Cellular and Molecular Pathology, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Jesse A PfammatterDepartment of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Mathew V JonesDepartment of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Rama K MagantiDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI.ORCID 0000-0001-5472-1645
University of Wisconsin–Madison · US

Funding

Sleep deprivation-induced seizure exacerbation: Targeting tonic inhibition as a therapeutic strategyR21NS104612 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI MAGANTI, RAMA · 2018 to 2019
$408k
NINDS NIH HHS R21 NS104612NINDS NIH HHS R21NS104612-01A1
6 · The paper itself

Abstract

Patients with epilepsy report that sleep deprivation is a common trigger for breakthrough seizures. The basic mechanism of this phenomenon is unknown. In the Kv1.1

Indexed as

AnimalsElectroencephalographyEpilepsyMiceReceptors, GABA-ASeizuresSleepSleep DeprivationReceptors, GABA-A

Identifiers

PMID34476841
PMCPMC8530964
OpenAlexW3196423233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.