Evidence map›Paper›PMID 34476728›Full record

Observational studySleep & breathing = Schlaf & Atmung2022

Sleep-disordered breathing and cerebral small vessel disease-acute and 6 months after ischemic stroke.

Sofie Amalie Simonsen, Adam Vittrup Andersen, Anders Sode West, Frauke Wolfram, Poul Jennum, Helle K Iversen

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Sleep & breathing = Schlaf & Atmung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02111408 (Stroke - Sleep Disorders, Dysfunction of the Autonomic Nervous System and Depression), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02111408 completednot on this map

Stroke - Sleep Disorders, Dysfunction of the Autonomic Nervous System and Depression

TypeobservationalSponsorHelle Klingenberg Iversen, MD, DmScRan2014 to 2022Enrolled114ConditionsStroke
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sofie Amalie SimonsenClinical Stroke Research Unit, Department of Neurology, Rigshospitalet, Valdemar Hansens Vej 1-23, 2600, Glostrup, Denmark. sofie.amalie.simonsen@regionh.dk.ORCID 0000-0002-1987-7318
Adam Vittrup AndersenClinical Stroke Research Unit, Department of Neurology, Rigshospitalet, Valdemar Hansens Vej 1-23, 2600, Glostrup, Denmark.
Anders Sode WestClinical Stroke Research Unit, Department of Neurology, Rigshospitalet, Valdemar Hansens Vej 1-23, 2600, Glostrup, Denmark.
Frauke WolframDepartment of Radiology, Rigshospitalet, Valdemar Hansens Vej 1-23, 2600, Glostrup, Denmark.
Poul JennumDanish Center for Sleep Medicine, Department of Neurophysiology, Rigshospitalet, Valdemar Hansens Vej 1-23, 2600, Glostrup, Denmark.
Helle K IversenClinical Stroke Research Unit, Department of Neurology, Rigshospitalet, Valdemar Hansens Vej 1-23, 2600, Glostrup, Denmark.
Rigshospitalet · DKGlostrup Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSleep-disordered breathing (SDB) occurs frequently after stroke and is associated with poor functional outcome and increased mortality. The purpose of this study was to detect changes in SDB over time after acute ischemic stroke and investigate relationships between SDB and stroke etiologies with focus on cerebral small vessel disease.

methodsFrom May 2015 to August 2016, we conducted an observational study of 99 patients with mild to moderate stroke (median age: 68 years, range 36-88; 56% men). Polysomnography was performed within 7 days of stroke onset (n = 91) and after 6 months (n = 52). The strokes were classified using the etiological TOAST classification. Total small vessel disease (SVD) scores were calculated based on MRIs.

resultsSDB, defined as an apnea-hypopnea index (AHI) ≥ 15, was found in 56% of patients in the acute state and in 44% at follow-up. AHI decreased over time (median change 4.7, 95% confidence interval [95% CI] 0.5-8.9; p = 0.03). Patients with AHI ≥ 15 in both the acute state and at follow-up had higher SVD score at follow-up (p = 0.003). AHI was not associated with ischemic stroke subgroups according to the TOAST classification. DISCUSSION: In conclusion, 6 months after stroke, AHI decreased, but 44% still had AHI ≥ 15. Persistent SDB in both the acute state and at follow-up was associated with a higher SVD score, but not to the TOAST subgroups. SDB evaluation should be offered to stroke patients, and the effect of SDB on cerebral small vessel disease needs to be further investigated using the well-defined SVD score.

trial registrationclinicaltrials.gov NCT02111408, April 11, 2014.

Indexed as

Cerebral Small Vessel DiseasesIschemic StrokeSleep Apnea SyndromesStrokeAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPolysomnographyCerebral small vessel diseaseIschemic strokeSleep apneaSleep-disordered breathing

Identifiers

PMID34476728
OpenAlexW3197148198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.